Intestinal inflammation in a murine model of autism spectrum disorders

Highlight • Prenatal valproic acid exposure in mice leads to male-specific intestinal inflammation and a disturbed serotonergic system in brain and intestine.

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Bibliographic Details
Published inBrain, behavior, and immunity Vol. 37; pp. 240 - 247
Main Authors de Theije, Caroline G.M, Koelink, Pim J, Korte-Bouws, Gerdien A.H, Lopes da Silva, Sofia, Korte, S. Mechiel, Olivier, Berend, Garssen, Johan, Kraneveld, Aletta D
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.03.2014
Subjects
Allergy and Immunology
Animals
Autism spectrum disorders
Brain - metabolism
Child Development Disorders, Pervasive - chemically induced
Child Development Disorders, Pervasive - complications
Disease Models, Animal
Female
Gut-brain axis
Ileitis - etiology
Ileitis - immunology
Ileitis - metabolism
Ileitis - pathology
Ileum - metabolism
Ileum - pathology
Intestinal tract
Male
Mice
Mice, Inbred BALB C
Neurodevelopment
Pregnancy
Prenatal
Psychiatry
Serotonin
Serotonin - metabolism
Social Behavior
Valproic Acid
Autism spectrum disorders
Prenatal
Serotonin
Gut-brain axis
Intestinal tract
Neurodevelopment
Valproic acid
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Summary:Highlight • Prenatal valproic acid exposure in mice leads to male-specific intestinal inflammation and a disturbed serotonergic system in brain and intestine.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2013.12.004