Multiple functions of nucleosomes and regulatory factors in transcription

The in vivo packaging of DNA with histone proteins to form chromatin makes its transcription a difficult process. Biochemical and genetic studies are beginning to reveal mechanistic details of how transcriptional regulatory factors confront at least two hurdles created by nucleosomes, the primary st...

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Bibliographic Details
Published inTrends in biochemical sciences (Amsterdam. Regular ed.) Vol. 18; no. 3; pp. 90 - 95
Main Authors Workman, Jerry L., Buchman, Andrew R.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.03.1993
Subjects
Animals
Drosophila
Gene Expression Regulation
Nucleosomes - metabolism
Saccharomyces cerevisiae
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:The in vivo packaging of DNA with histone proteins to form chromatin makes its transcription a difficult process. Biochemical and genetic studies are beginning to reveal mechanistic details of how transcriptional regulatory factors confront at least two hurdles created by nucleosomes, the primary structural unit of chromatin. Regulatory factors must gain access to their respective binding sites and activate the formation of transcription complexes at core promoter elements. Distinct regulatory factors may be specialized to perform these functions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-2
ISSN:0968-0004
1362-4326
DOI:10.1016/0968-0004(93)90160-O