Cytokines and Chemokines in Uveitis – Is there a Correlation with Clinical Phenotype?
Uveitis is a general term for intraocular inflammation and includes a large number of clinical phenotypes. As a group of disorders, it is responsible for 10% of all registered blind patients under the age of 65 years. Immune-mediated uveitis may be associated with a systemic disease or may be locali...
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Published in | Clinical medicine & research Vol. 4; no. 4; pp. 294 - 309 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Marshfield Clinic
01.12.2006
2006. Clinical Medicine & Research |
Subjects | |
Online Access | Get full text |
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Summary: | Uveitis is a general term for intraocular inflammation and includes a large number of clinical phenotypes. As a group of disorders, it is responsible for 10% of all registered blind patients under the age of 65 years. Immune-mediated uveitis may be associated with a systemic disease or may be localized to the eye. The pro-inflammatory cytokines interleukin (IL)-1beta, IL-2, IL-6, interferon-gamma and tumor necrosis factor-alpha have all been detected within the ocular fluids or tissues in the inflamed eye together with others, such as IL-4, IL-5, IL-10 and transforming growth factor-beta. The chemokines IL-8, monocyte chemoattractant protein-1, macrophage inflammatory protein (MIP)-1alpha, MIP-1beta and fractalkine are also thought to be involved in the associated inflammatory response. There have been a number of studies in recent years investigating cytokine profiles in different forms of uveitis with a view to determining what cytokines are important in the inflamed eye. This review attempts to present the current state of knowledge from in vitro and in vivo research on the inflammatory cytokines in intraocular inflammatory diseases. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Reprint Requests: Susan L. Lightman, PhD, Department of Clinical Ophthalmology, Moorfields Eye Hospital, City Rd, London, UK EC1V 2PD, Tel.: 44-20-7566-2266, Fax: 44-20-7251-9350, Email: s.lightman@ucl.ac.uk |
ISSN: | 1539-4182 1554-6179 |
DOI: | 10.3121/cmr.4.4.294 |