Antagonists of TNFα for recurrent miscarriages: 2 Illustrative cases

Approximately 1 to 3% of women have recurrent early miscarriages, defined as ≥3 pregnancy losses before 14 weeks of gestation. The immune deregulation and tolerance rupture could be the origin of these miscarriages in at least 30% of these women. Chronic intervillositis of unknown etiology (CIUE) is...

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Bibliographic Details
Published inEuropean journal of obstetrics & gynecology and reproductive biology Vol. 236; pp. 263 - 264
Main Authors Mekinian, Arsène, Houfflin-Debarge, Véronique, Kolanska, Kamilla, Cohen, Jonathan, Abisror, Noémie, Bornes, Marie, Kayem, Gilles, Fain, Olivier
Format Journal Article
LanguageEnglish
Published Ireland Elsevier B.V 01.05.2019
Subjects
Adalimumab
Chronic intervillositis
Miscarriages
Outcome
Chronic intervillositis
Adalimumab
Outcome
Miscarriages
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Summary:Approximately 1 to 3% of women have recurrent early miscarriages, defined as ≥3 pregnancy losses before 14 weeks of gestation. The immune deregulation and tolerance rupture could be the origin of these miscarriages in at least 30% of these women. Chronic intervillositis of unknown etiology (CIUE) is a rare placental lesion characterized by intrauterine deaths, growth restriction and high recurrence rate. In cases with recurrent obstetrical adverse events and intrauterine deaths, we previously reported the benefit of hydroxychloroquine combination to prednisone. Even few data raised the potential value of TNF antagonists in early recurrent miscarriages, these cases show its potential value in the setting of recurrent refractory chronic intervillositis and unexplained miscarriages.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2019.02.036