Stem Cells in Dermatology and Anti-aging Care of the Skin

Multipotent stem cells have paved the way for new applications and deeper understanding in regenerative medicine and the pathophysiology of aging. During skin aging, cumulative photodamage, exhaustion of endogenous stem cell populations, mechanical stress, and increased fibrosis lead to skin with de...

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Bibliographic Details
Published inFacial plastic surgery clinics of North America Vol. 26; no. 4; p. 425
Main Authors Taub, Amy Forman, Pham, Kim
Format Journal Article
LanguageEnglish
Published United States 01.11.2018
Subjects
Defensins - metabolism
Epidermal Cells - metabolism
Hair Follicle - cytology
Humans
Receptors, G-Protein-Coupled - metabolism
Rejuvenation
Skin Aging
Stem Cells - metabolism
Anti-microbial peptide
Epidermal thickness
Wrinkles
Pore reduction
Stem cells
Anti-aging skin care
Defensin
Melanin
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Summary:Multipotent stem cells have paved the way for new applications and deeper understanding in regenerative medicine and the pathophysiology of aging. During skin aging, cumulative photodamage, exhaustion of endogenous stem cell populations, mechanical stress, and increased fibrosis lead to skin with decreased epidermal thickness and compromised dermal integrity. Specific stem cells in the hair follicle create new keratinocytes after activation by defensin peptides, released by neutrophils during wounding. Studies pertaining to defensin peptides' efficacy on skin aging have been published, highlighting their potential as a new therapy for skin rejuvenation.
ISSN:1558-1926
DOI:10.1016/j.fsc.2018.06.004