Relation of atrophic gastritis with Helicobacter pylori-CagA(+) and interleukin-1 gene polymorphisms

• Published in: World journal of gastroenterology : WJG Vol. 14; no. 42; pp. 6481 - 6487
• Main Authors: Sierra, Rafaela, Une, Clas, Ramirez, Vanessa, Alpizar-Alpizar, Warner, Gonzalez, Maria-I, Ramirez, Jose-A, De Mascarel, Antoine, Cuenca, Patricia, Perez-Perez, Guillermo, Megraud, Francis
• Format: Journal Article
• Language: English
• Published: United States Institute of Health Research,University of Costa Pica,San Jose 2060,Costa Pica%Department of Statistics,University of Costa Pica,San Jose 2060,Costa Pica%Department of Pathology,Calderón Guardia Hospital,Costa Pica,San José 2060,Costa Pica%University Victor Segalen Bordeaux 2,146,rue Leo-Saignat,Case 76,Bordeaux Cedex 33076,France%Departments of Medicine and Microbiology,New York University School of Medicine,NYU.Langone Medical Center,550 First Avenue,New York 10016,United States 14.11.2008; The WJG Press and Baishideng
• Subjects: Alcohol Drinking - adverse effects; Antigens, Bacterial - genetics; Atrophy; Bacterial Proteins - genetics; Biopsy; Costa Rica; Diet - adverse effects; Dyspepsia - genetics; Dyspepsia - immunology; Dyspepsia - microbiology; Female; Gastritis - genetics; Gastritis - immunology; Gastritis - microbiology; Gastritis - pathology; Gastroscopy; Genetic Predisposition to Disease; Helicobacter Infections - complications; Helicobacter Infections - genetics; Helicobacter Infections - immunology; Helicobacter Infections - microbiology; Helicobacter Pylori; Helicobacter pylori - genetics; Humans; Interleukin 1 Receptor Antagonist Protein - genetics; Interleukin-1beta - genetics; Logistic Models; Male; Middle Aged; Odds Ratio; Pepsinogen A - blood; Pepsinogen C - blood; Peptic Ulcer - genetics; Peptic Ulcer - immunology; Peptic Ulcer - microbiology; Polymorphism, Genetic; Risk Assessment; Risk Factors; Smoking - adverse effects; Surveys and Questionnaires; Costa Rica; Pepticulcers; Interleukins; Pepsinogen; Atrophic gastritis; Helicobacter pylori-CagA

To determine the association of Helicobacter pylori (H pylori) CagA(+) infection and pro-inflammatory polymorphisms of the genes interleukin (IL)-1RN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of g...