Timely orchiopexy by 18 months of age: Are we meeting the standards defined by the 2014 AUA guidelines?

• Published in: Journal of pediatric urology Vol. 18; no. 5; pp. 683.e1 - 683.e7
• Main Authors: Williamson, Sarah H., Davis-Dao, Carol A., Huen, Kathy H., Ehwerhemuepha, Louis, Chuang, Kai-wen, Stephany, Heidi A., Wehbi, Elias J., Kain, Zeev N.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2022
• Subjects: Adolescent; Child; Child, Preschool; Cryptorchidism - diagnosis; Cryptorchidism - surgery; Health disparities; Humans; Infant; Infant, Newborn; Male; Orchiopexy; Pediatric urology; Referral and Consultation; Retrospective Studies; Pediatric urology; CRWD; CPT; Orchiopexy; IQR; ICD; AUA; Health disparities
• ISSN: 1477-5131; 1873-4898
• DOI: 10.1016/j.jpurol.2022.07.008

Cryptorchidism is one of the most common reasons for pediatric urology referral and one of the few pediatric urologic conditions in which there are established AUA guidelines that recommend orchiopexy be performed before 18 months of age. While access to timely orchiopexy has been studied previously, there is no current study with data from a national clinical database evaluating timely orchiopexy after the AUA guidelines were published. Additionally, prior studies on delayed orchiopexy may have included patients with an ascended testis, which is a distinct population from those with true undescended testicles. [Display omitted] To evaluate in a national, clinical database if timely orchiopexy improved after the AUA guidelines were published in 2014. In particular, we aim to evaluate a younger group of patients, 0–5 years of age, in an effort to account for potential ascending testes. Using Cerner Real-World Data™, a national, de-identified database of 153 million individuals, we analyzed pediatric patients undergoing orchiopexy in the United States from 2000 to 2021. We included males 0–18 years old and further focused on the subset 0–5 years. Primary outcome was timely orchiopexy, defined as age at orchiopexy less than 18 months. Predictor variables included race, ethnicity and insurance status. Statistical analyses were performed using logistic regression. Of the total 17,012 individuals identified as undergoing orchiopexy, 9274 were ages 0–5 at the time of surgery. Comparing time periods pre and post AUA guidelines (2000–2014 versus 2015–2021), we found a significant difference in the proportion of timely orchiopexy (51% versus 56%, respectively; p < 0.0001) (Figure). In multivariable analyses, Hispanic (OR = 0.65, p < 0.0001), African American (OR = 0.74, p < 0.0001), and Native American males (OR = 0.66, p = 0.008) were less likely to have timely orchiopexy compared to non-Hispanic White males. Individuals without insurance (OR = 0.81, p = 0.03) or with public insurance (OR = 0.88, p = 0.02) were less likely to have timely orchiopexy as compared to those with private insurance. Nearly a decade after publication of the AUA cryptorchidism guidelines, a large proportion of patients are still not undergoing orchiopexy by 18 months of age. This is the first study to show that timely orchiopexy has improved among patients 0–5 years, but the majority of patients are still not undergoing timely orchiopexy. Health disparities were apparent among Hispanic, African American, Native American, and uninsured males, highlighting the need for further progress in access to pediatric surgical care.