How yeast can be used as a genetic platform to explore virus–host interactions: from ‘omics’ to functional studies

Highlights • Several RNA viruses of plants and animals can replicate in yeast cells. • Systematic genome-wide screens of yeast genes are powerful tools for identifying host factors. • Global proteomics screens in yeast strengthen the datasets from genomics screens. • Functional studies in yeast can...

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Bibliographic Details
Published inTrends in microbiology (Regular ed.) Vol. 22; no. 6; pp. 309 - 316
Main Authors Nagy, Peter D, Pogany, Judit, Lin, Jing-Yi
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2014
Subjects
Computational Biology
Genome, Fungal
genome-wide screens
Genomics
host factors
Host-Pathogen Interactions - genetics
Internal Medicine
Models, Genetic
protein–protein interaction
RNA–protein interaction
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - virology
viral replicase complex
virus replication
Virus Replication - genetics
yeast as a host
viral replicase complex
yeast as a host
virus replication
genome-wide screens
protein–protein interaction
host factors
RNA–protein interaction
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Summary:Highlights • Several RNA viruses of plants and animals can replicate in yeast cells. • Systematic genome-wide screens of yeast genes are powerful tools for identifying host factors. • Global proteomics screens in yeast strengthen the datasets from genomics screens. • Functional studies in yeast can lead to novel insights into virus–host interactions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-2
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2014.02.003