Genetics/genomics/proteomics of gastric adenocarcinoma

• Published in: Gastroenterology clinics of North America Vol. 42; no. 2; p. 241
• Main Authors: Uppal, Dushant S, Powell, Steven M
• Format: Journal Article
• Language: English
• Published: United States 01.06.2013
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - metabolism; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cadherins - genetics; DNA Methylation - genetics; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genomic Instability; Genomics; Humans; Neoplastic Syndromes, Hereditary - genetics; Protein Array Analysis; Protein Kinases - genetics; Protein Tyrosine Phosphatases - genetics; Signal Transduction - genetics; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Transcriptome; Trefoil Factor-1; Tumor Suppressor Proteins - genetics
• ISSN: 1558-1942
• DOI: 10.1016/j.gtc.2013.01.005

Hereditary diffuse gastric cancer can be caused by epithelial cadherin mutations for which genetic testing is available. Inherited cancer predisposition syndromes including Lynch, Li-Fraumeni, and Peutz-Jeghers syndromes, can be associated with gastric cancer. Chromosomal and microsatellite instability occur in gastric cancers. Several consistent genetic and molecular alterations including chromosomal instability, microsatellite instability, and epigenetic alterations have been identified in gastric cancers. Biomarkers and molecular profiles are being discovered with potential for diagnostic, prognostic, and treatment guidance implications.