Coagulation and immunity: Caught in the fibrin web

In this issue of Immunity, Vega-Pérez et al. (2021) reveal the formation of a dynamic multicellular aggregate within a fibrin scaffold consisting of large peritoneal macrophages, B1 cells, neutrophils, and monocytes during antibacterial immunity in the peritoneum. Anticoagulants targeting thrombin o...

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Published inImmunity (Cambridge, Mass.) Vol. 54; no. 11; pp. 2439 - 2441
Main Authors Sozmen, Elif G., Akassoglou, Katerina
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 09.11.2021
Subjects
Animals
Blood Coagulation
Escherichia coli
Fibrin
Mice
Mice, Inbred C57BL
Monocytes
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Summary:In this issue of Immunity, Vega-Pérez et al. (2021) reveal the formation of a dynamic multicellular aggregate within a fibrin scaffold consisting of large peritoneal macrophages, B1 cells, neutrophils, and monocytes during antibacterial immunity in the peritoneum. Anticoagulants targeting thrombin or peritoneal macrophage depletion by clodronate impaired efficient control of E. coli infection. In this issue of Immunity, Vega-Pérez et al. (2021) reveal the formation of a dynamic multicellular aggregate within a fibrin scaffold consisting of large peritoneal macrophages, B1 cells, neutrophils, and monocytes during antibacterial immunity in the peritoneum. Anticoagulants targeting thrombin or peritoneal macrophage depletion by clodronate impaired efficient control of E. coli infection.
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ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2021.10.016