Using metabolomics to dissect host–parasite interactions
Highlights • Metabolomic approaches have highlighted aspects of parasite metabolism essential for virulence. • Most mammalian infective parasite stages are dependent on sugars as primary carbon sources. • Key metabolic fluxes are regulated by metabolic rather than transcriptional mechanisms. • Signi...
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Published in | Current opinion in microbiology Vol. 32; pp. 59 - 65 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.08.2016
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Subjects | |
Online Access | Get full text |
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Summary: | Highlights • Metabolomic approaches have highlighted aspects of parasite metabolism essential for virulence. • Most mammalian infective parasite stages are dependent on sugars as primary carbon sources. • Key metabolic fluxes are regulated by metabolic rather than transcriptional mechanisms. • Significant differences in host and parasite central carbon metabolism offer opportunities for drug development. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 1369-5274 1879-0364 |
DOI: | 10.1016/j.mib.2016.04.019 |