Oxygen Therapy and Pulmonary Hypertension in Preterm Infants

The goal of oxygen therapy and oxygen saturation targeting in extremely preterm infants is to improve outcomes and balance the risks associated with both hypoxemia and hyperoxemia. Although the NeOProM trials addressed whether low or high oxygen saturation targets affect the most important outcomes...

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Bibliographic Details
Published inClinics in perinatology Vol. 46; no. 3; p. 611
Main Authors Gentle, Samuel J, Abman, Steven H, Ambalavanan, Namasivayam
Format Journal Article
LanguageEnglish
Published United States 01.09.2019
Subjects
Humans
Hypertension, Pulmonary - therapy
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - therapy
Oxygen Inhalation Therapy - methods
Bronchopulmonary dysplasia
Infant
Oxygen
Infant mortality
Extremely premature
Bronchopulmonary-associated pulmonary hypertension
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Summary:The goal of oxygen therapy and oxygen saturation targeting in extremely preterm infants is to improve outcomes and balance the risks associated with both hypoxemia and hyperoxemia. Although the NeOProM trials addressed whether low or high oxygen saturation targets affect the most important outcomes of extreme prematurity including death and other co-morbidities, the trials did not evaluate infants for pulmonary hypertension. There is limited evidence for the optimal oxygen saturation targets in extremely preterm infants that can be used to prevent the development of pulmonary hypertension and manage pulmonary hypertension once developed.
ISSN:1557-9840
DOI:10.1016/j.clp.2019.05.009