Organization of human class I homeobox genes

We report the genomic organization of 20 human class I homeoboxes and the predicted primary sequence of the encoded homeodomains. These homeoboxes are clustered in four complex HOX loci on chromosomes 2, 7, 12, and 17. The homeoboxes of one HOX locus can be aligned to the homeoboxes of the other HOX...

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Bibliographic Details
Published inGenome Vol. 31; no. 2; p. 745
Main Authors Boncinelli, E, Acampora, D, Pannese, M, D'Esposito, M, Somma, R, Gaudino, G, Stornaiuolo, A, Cafiero, M, Faiella, A, Simeone, A
Format Journal Article
LanguageEnglish
Published Canada 01.01.1989
Subjects
Amino Acid Sequence
Animals
Base Sequence
Chromosome Mapping
Drosophila melanogaster - genetics
Genes, Homeobox
Humans
Mammals - genetics
Mice - genetics
Molecular Sequence Data
Phylogeny
Sequence Homology, Nucleic Acid
Species Specificity
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Summary:We report the genomic organization of 20 human class I homeoboxes and the predicted primary sequence of the encoded homeodomains. These homeoboxes are clustered in four complex HOX loci on chromosomes 2, 7, 12, and 17. The homeoboxes of one HOX locus can be aligned to the homeoboxes of the other HOX loci so that corresponding homeodomains in all loci can share the maximal peptide sequence identity. This correspondence of individual homeoboxes in different chromosomal loci suggests the hypothesis of large-scale duplications of a single complex locus. The existence of an ancestral complex locus might have predated the divergence of vertebrates and invertebrates.
ISSN:0831-2796
1480-3321
DOI:10.1139/g89-133