Modulating the Modulator: Regulation of Protein Methylation by Nitric Oxide

Protein methylation is an important modulator of signal transduction pathways, but methyltransferases themselves may also be modulated. Hu et al. (2017) demonstrate in this issue of Molecular Cell that S-nitrosylation selectively modulates enzymatic activity of a protein arginine methyltransferase v...

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Bibliographic Details
Published inMolecular cell Vol. 67; no. 4; pp. 535 - 537
Main Authors Frungillo, Lucas, Spoel, Steven H.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 17.08.2017
Subjects
Arginine
Methylation
Protein-Arginine N-Methyltransferases
Signal Transduction
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Summary:Protein methylation is an important modulator of signal transduction pathways, but methyltransferases themselves may also be modulated. Hu et al. (2017) demonstrate in this issue of Molecular Cell that S-nitrosylation selectively modulates enzymatic activity of a protein arginine methyltransferase vital to abiotic stress tolerance. Protein methylation is an important modulator of signal transduction pathways, but methyltransferases themselves may also be modulated. Hu et al. (2017) demonstrate in this issue of Molecular Cell that S-nitrosylation selectively modulates enzymatic activity of a protein arginine methyltransferase vital to abiotic stress tolerance.
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ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2017.08.001