Celiac Disease and Nonceliac Gluten Sensitivity

Gluten-related disorders include celiac disease (CD), wheat allergy, and nonceliac gluten sensitivity. CD is an autoimmune enteropathy caused by damage to small intestinal mucosa when gluten is ingested in genetically susceptible individuals. Currently, the only available treatment of CD is gluten-f...

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Bibliographic Details
Published inThe Pediatric clinics of North America Vol. 64; no. 3; p. 563
Main Authors Watkins, Runa D, Zawahir, Shamila
Format Journal Article
LanguageEnglish
Published United States 01.06.2017
Subjects
Celiac Disease - diagnosis
Celiac Disease - therapy
Diet, Gluten-Free - methods
Female
Glutens
Humans
Male
Polyendocrinopathies, Autoimmune - diagnosis
Polyendocrinopathies, Autoimmune - therapy
Wheat Hypersensitivity - diagnosis
Wheat Hypersensitivity - therapy
Celiac disease
Wheat allergy
Nonceliac gluten sensitivity
Gluten-free diet
Tissue transglutaminase
Autoimmune
Children
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Summary:Gluten-related disorders include celiac disease (CD), wheat allergy, and nonceliac gluten sensitivity. CD is an autoimmune enteropathy caused by damage to small intestinal mucosa when gluten is ingested in genetically susceptible individuals. Currently, the only available treatment of CD is gluten-free diet. Several potential treatments are being researched. Wheat allergy is a hypersensitivity reaction caused by IgE-mediated and/or non-IgE-mediated immune response, and can involve the gastrointestinal tract, skin, or respiratory tract. Nonceliac gluten sensitivity is one of a variety of immunologic, morphologic, or symptomatic manifestations precipitated by ingestion of gluten in individuals in whom CD and wheat allergy are excluded.
ISSN:1557-8240
DOI:10.1016/j.pcl.2017.01.013