Does Amiodarone Influence Early Mortality in Heart Transplantation?

The use of amiodarone before transplantation has been linked to an increased number of complications, acute graft failures, and early mortality after a heart graft. We undertook a retrospective, descriptive, case-controlled study involving early mortality and acute graft failure. The 396 consecutive...

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Bibliographic Details
Published inTransplantation proceedings Vol. 38; no. 8; pp. 2537 - 2538
Main Authors Sánchez-Lázaro, I.J., Almenar, L., Martinez-Dolz, L., Chamorro, C., Moro, J., Agüero, J., Rueda, J., Zorio, E., Arnau, M.A., Salvador, A.
Format Journal Article Conference Proceeding
LanguageEnglish
Published New York, NY Elsevier Inc 01.10.2006
Elsevier Science
Subjects
Amiodarone - adverse effects
Anti-Arrhythmia Agents - adverse effects
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Heart Transplantation - mortality
Humans
Medical sciences
Multivariate Analysis
Patient Selection
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Survival Analysis
Tissue, organ and graft immunology
Ventricular Dysfunction, Left - drug therapy
Antianginal agent
Heart
Prognosis
Coronary vasodilator agent
Mortality
Amiodarone
Transplantation
Antiarrhythmic agent
Homotransplantation
Iodine Organic compounds
Epidemiology
Medicine
Treatment
Surgery
Graft
Early
Circulatory system
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Summary:The use of amiodarone before transplantation has been linked to an increased number of complications, acute graft failures, and early mortality after a heart graft. We undertook a retrospective, descriptive, case-controlled study involving early mortality and acute graft failure. The 396 consecutive patients included 25 subjects who had been prescribed amiodarone for at least 30 days before transplantation. We excluded retransplantations, pediatric transplantations, and combined transplantations. The endpoints were early mortality and acute graft failure. No significant differences were observed in early mortality and acute graft failures. The multivariate analysis did not reveal any variable that correlated with early mortality. Our study did not support the idea that amiodarone constituted a negative predictor of early survival or acute graft failure.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2006.08.022