Neurotransmitter signaling: a new frontier in colorectal cancer biology and treatment

The brain–gut axis, a bidirectional network between the central and enteric nervous system, plays a critical role in modulating the gastrointestinal tract function and homeostasis. Recently, increasing evidence suggests that neuronal signaling molecules can promote gastrointestinal cancers, however,...

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Published inOncogene Vol. 41; no. 43; pp. 4769 - 4778
Main Authors Battaglin, Francesca, Jayachandran, Priya, Strelez, Carly, Lenz, Annika, Algaze, Sandra, Soni, Shivani, Lo, Jae Ho, Yang, Yan, Millstein, Joshua, Zhang, Wu, Roussos Torres, Evanthia T, Shih, Jean C, Mumenthaler, Shannon M, Neman, Josh, Lenz, Heinz-Josef
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group 21.10.2022
Subjects
Alzheimer's disease
Angiogenesis
Apoptosis
Autophagy
Biology
Brain cancer
Cancer
Cell cycle
Cell growth
Cell migration
Cell proliferation
Colorectal cancer
Colorectal carcinoma
Cytokines
Cytotoxicity
Dopamine
Endothelial cells
Enteric nervous system
Gastrointestinal tract
Homeostasis
Inflammation
Medicine
Metastases
Metastasis
Microbiota
Motility
Nervous system
Neurotransmitters
Tumor microenvironment
Tumorigenesis
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Summary:The brain–gut axis, a bidirectional network between the central and enteric nervous system, plays a critical role in modulating the gastrointestinal tract function and homeostasis. Recently, increasing evidence suggests that neuronal signaling molecules can promote gastrointestinal cancers, however, the mechanisms remain unclear. Aberrant expression of neurotransmitter signaling genes in colorectal cancer supports the role of neurotransmitters to stimulate tumor growth and metastatic spread by promoting cell proliferation, migration, invasion, and angiogenesis. In addition, neurotransmitters can interact with immune and endothelial cells in the tumor microenvironment to promote inflammation and tumor progression. As such, pharmacological targeting of neurotransmitter signaling represent a promising novel anticancer approach. Here, we present an overview of the current evidence supporting the role of neurotransmitters in colorectal cancer biology and treatment.
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AUTHOR CONTRIBUTIONS
FB drafted the paper with the aid of CS and AL. HJL supervised the paper. All authors directly provided their contribution, read and approved the final paper.
ISSN:0950-9232
1476-5594
DOI:10.1038/s41388-022-02479-4