Proteomics approaches to characterize the immune responses in cancer

Despite the dynamic development of cancer research, annually millions of people die of cancer. The human immune system is the major ‘guard’ against tumor development. Unfortunately, cancer cells have the ability to evade the immune system and continue to grow. The proper understanding of the intrica...

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Published inBiochimica et biophysica acta. Molecular cell research Vol. 1869; no. 8; p. 119266
Main Authors Urbiola-Salvador, Víctor, Miroszewska, Dominika, Jabłońska, Agnieszka, Qureshi, Talha, Chen, Zhi
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.08.2022
Subjects
Cancer
Humans
Immunity
Immunotherapy
Neoplasms - metabolism
Proteomics
Single-cell
T cells
Tumor Microenvironment - genetics
ILC
TAM
ALN
IHC
nanoPOTS
MHC
RPPA
FASLG
SCoPE-MS
Immunity
LC-MS/MS
NF-κB
IFN-γ
PLAYR
Th
FFPE
MC
mPOP
Immunotherapy
IC
IMC
AML
BAFF
ARG2
REAP-seq
IL
CAC
MALDI-TOF
CITE-seq
MS
scATAC-seq
MELC
PBMC
EV
GAM
SAA
TGF
CRC
LCM
SCBC
NGS
CyTOF
FC
NK
PD-1
SIRT
IgE
MIBI
NAPPA
PTM
SISPROT
mIF
T cells
Single-cell
Tim-3
GBM
LAG-3
PD-L1
MIST
CTLA-4
ESI
SN
ABCD
FoxP3
CODEX
CD
MSI
Treg
2-DE
FSFC
CCL
PEA
TME
mAb
APC
TIL
Proteomics
LAP
SUGAR-seq
Cancer
Online AccessGet full text

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Abstract Despite the dynamic development of cancer research, annually millions of people die of cancer. The human immune system is the major ‘guard’ against tumor development. Unfortunately, cancer cells have the ability to evade the immune system and continue to grow. The proper understanding of the intricate immune response in tumorigenesis remains the holy grail of cancer immunology and designing effective immunotherapy. To decode the immune responses in cancer, in recent years, proteomics studies have received considerable attention. Proteomics studies focus on the detection and quantification of proteins, which are the effectors of biological functions, and as such, are proven to reflect the cell state more accurately, in comparison to genomic or transcriptomic studies. In this review, we discuss the proteomics studies applied to characterize the immune responses in cancer and tumor immune microenvironment heterogeneity. Further, we describe emerging single-cell proteomics approaches that have the potential to be applied in cancer immunity studies. •Proteomics approaches enable to uncover novel insights in cancer immunology.•Mass spectrometry unveils immune mechanisms and novel immunotherapeutic targets.•Antibody-based strategies determine predictive biomarker panels for immunotherapy.•Single-cell proteomics is a key to understanding the tumor microenvironment.•Single-cell multi-omics will revolutionize the studies on cancer immunology.
AbstractList Despite the dynamic development of cancer research, annually millions of people die of cancer. The human immune system is the major ‘guard’ against tumor development. Unfortunately, cancer cells have the ability to evade the immune system and continue to grow. The proper understanding of the intricate immune response in tumorigenesis remains the holy grail of cancer immunology and designing effective immunotherapy. To decode the immune responses in cancer, in recent years, proteomics studies have received considerable attention. Proteomics studies focus on the detection and quantification of proteins, which are the effectors of biological functions, and as such, are proven to reflect the cell state more accurately, in comparison to genomic or transcriptomic studies. In this review, we discuss the proteomics studies applied to characterize the immune responses in cancer and tumor immune microenvironment heterogeneity. Further, we describe emerging single-cell proteomics approaches that have the potential to be applied in cancer immunity studies. •Proteomics approaches enable to uncover novel insights in cancer immunology.•Mass spectrometry unveils immune mechanisms and novel immunotherapeutic targets.•Antibody-based strategies determine predictive biomarker panels for immunotherapy.•Single-cell proteomics is a key to understanding the tumor microenvironment.•Single-cell multi-omics will revolutionize the studies on cancer immunology.
Despite the dynamic development of cancer research, annually millions of people die of cancer. The human immune system is the major 'guard' against tumor development. Unfortunately, cancer cells have the ability to evade the immune system and continue to grow. The proper understanding of the intricate immune response in tumorigenesis remains the holy grail of cancer immunology and designing effective immunotherapy. To decode the immune responses in cancer, in recent years, proteomics studies have received considerable attention. Proteomics studies focus on the detection and quantification of proteins, which are the effectors of biological functions, and as such, are proven to reflect the cell state more accurately, in comparison to genomic or transcriptomic studies. In this review, we discuss the proteomics studies applied to characterize the immune responses in cancer and tumor immune microenvironment heterogeneity. Further, we describe emerging single-cell proteomics approaches that have the potential to be applied in cancer immunity studies.
ArticleNumber 119266
Author Urbiola-Salvador, Víctor
Chen, Zhi
Qureshi, Talha
Miroszewska, Dominika
Jabłońska, Agnieszka
Author_xml – sequence: 1
  givenname: Víctor
  surname: Urbiola-Salvador
  fullname: Urbiola-Salvador, Víctor
  email: v.urbiolasalvador.373@studms.ug.edu.pl
  organization: Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Poland
– sequence: 2
  givenname: Dominika
  surname: Miroszewska
  fullname: Miroszewska, Dominika
  email: d.miroszewska.263@studms.ug.edu.pl
  organization: Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Poland
– sequence: 3
  givenname: Agnieszka
  surname: Jabłońska
  fullname: Jabłońska, Agnieszka
  email: a.jablonska@ug.edu.pl
  organization: Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Poland
– sequence: 4
  givenname: Talha
  surname: Qureshi
  fullname: Qureshi, Talha
  email: talha.qureshi@oulu.fi
  organization: Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland
– sequence: 5
  givenname: Zhi
  surname: Chen
  fullname: Chen, Zhi
  email: zhi.chen@oulu.fi
  organization: Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Poland
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35390423$$D View this record in MEDLINE/PubMed
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Keywords ILC
TAM
ALN
IHC
nanoPOTS
MHC
RPPA
FASLG
SCoPE-MS
Immunity
LC-MS/MS
NF-κB
IFN-γ
PLAYR
Th
FFPE
MC
mPOP
Immunotherapy
IC
IMC
AML
BAFF
ARG2
REAP-seq
IL
CAC
MALDI-TOF
CITE-seq
MS
scATAC-seq
MELC
PBMC
EV
GAM
SAA
TGF
CRC
LCM
SCBC
NGS
CyTOF
FC
NK
PD-1
SIRT
IgE
MIBI
NAPPA
PTM
SISPROT
mIF
T cells
Single-cell
Tim-3
GBM
LAG-3
PD-L1
MIST
CTLA-4
ESI
SN
ABCD
FoxP3
CODEX
CD
MSI
Treg
2-DE
FSFC
CCL
PEA
TME
mAb
APC
TIL
Proteomics
LAP
SUGAR-seq
Cancer
Language English
License This is an open access article under the CC BY-NC-ND license.
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
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Yuan (bb0665) 2016; 6
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Wiśniewski (bb0175) 2019; 1090
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Thompson, Schäfer, Kuhn, Kienle, Schwarz, Schmidt, Neumann, Hamon (bb0800) 2003; 75
Chen, Mellman (bb0090) 2017; 541
Vickman, Faget, Beachy, Beebe, Bhowmick, Cukierman, Deng, Granneman, Hildesheim, Kalluri, Lau, Lengyel, Lundeberg, Moscat, Nelson, Pietras, Politi, Puré, Scherz-Shouval, Sherman, Tuveson, Weeraratna, White, Wong, Woodhouse, Zheng, Hayward, Stewart (bb0555) 2020; 11
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Snippet Despite the dynamic development of cancer research, annually millions of people die of cancer. The human immune system is the major ‘guard’ against tumor...
Despite the dynamic development of cancer research, annually millions of people die of cancer. The human immune system is the major 'guard' against tumor...
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StartPage 119266
SubjectTerms Cancer
Humans
Immunity
Immunotherapy
Neoplasms - metabolism
Proteomics
Single-cell
T cells
Tumor Microenvironment - genetics
Title Proteomics approaches to characterize the immune responses in cancer
URI https://dx.doi.org/10.1016/j.bbamcr.2022.119266
https://www.ncbi.nlm.nih.gov/pubmed/35390423
https://search.proquest.com/docview/2648898552
Volume 1869
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