MiR-1273 g-3p Promotes Malignant Progression and has Prognostic Implications in Prostate Cancer

• Published in: Molecular biotechnology Vol. 64; no. 1; pp. 17 - 24
• Main Authors: Chang, Yaxue, Deng, Qian, Guan, Zhenfeng, Cheng, Yongyi, Sun, Yi
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2022; Springer Nature B.V
• Subjects: Aged; Biochemistry; Biological effects; Biological Techniques; Biomarkers, Tumor - genetics; Biotechnology; Cell Biology; Cell growth; Cell Line, Tumor; Cell migration; Cell Movement - genetics; Cell proliferation; Cell Proliferation - genetics; Chemistry; Chemistry and Materials Science; Cholecystokinin; Human Genetics; Humans; Lymph nodes; Lymphatic Metastasis; Male; Metastases; metastasis; MicroRNAs - genetics; Middle Aged; Neoplasm Staging; oncogenes; Original Paper; Patients; Prognosis; Prostate cancer; prostatic neoplasms; Prostatic Neoplasms - genetics; Prostatic Neoplasms - mortality; Prostatic Neoplasms - pathology; Protein Science; quantitative polymerase chain reaction; Regression analysis; Survival; Survival Rate; Therapeutic targets; therapeutics; Up-Regulation; Prognosis; Proliferation; Prostate cancer; Migration; Invasion; miR-1273 g-3p
• ISSN: 1073-6085; 1559-0305; 1559-0305
• DOI: 10.1007/s12033-021-00384-x

Prostate cancer (PCa) is the most popular cancer of mankind. Our study aimed to provide the expression and the predictive significance of miR-1273 g-3p in PCa. Moreover, the effects on cell biological activities were also investigated. The relative expression of miR-1273 g-3p in PCa tissues and cell lines was validated by quantitative real-time PCR. Kaplan–Meier curve and Cox regression analyses were performed to indicate the prognostic value. The implications of miR-1273 g-3p on cell proliferation, migration, and invasion were validated using the CCK-8 and Transwell assay. Our results provided that the expression of miR-1273 g-3p was increased in PCa tissues and cell lines. The levels of miR-1273 g-3p were associated with Gleason score, TNM stage, clinical stage, and lymph node metastasis. Overexpression of miR-1273 g-3p indicated a promising overall survival rate. Cox regression results indicated miR-1273 g-3p might be an independent marker for PCa patients. Silenced miR-1273 g-3p inhibited PCa cell proliferation, migration, and invasion. In total, miR-1273 g-3p was increased in PCa and identified as a therapeutic target and a prognostic factor for PCa patients. Overexpression of miR-1273 g-3p might be an oncogene via accelerating cell proliferation, migration, and invasion.