The coculture: a system for studying the regulation of liver differentiation/proliferation activity and its control

The coculture, the principle of which is to restore in vitro cell-cell interaction signals present in vivo, is not only a culture model system: it also has the great advantage of mimicking the physiological situation. Indeed, the participation of proximal and/or contacting cells in the control of de...

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Bibliographic Details
Published inCell biology and toxicology Vol. 13; no. 4-5; pp. 235 - 242
Main Authors Corlu, A, Ilyin, G, Cariou, S, Lamy, I, Loyer, P, Guguen-Guillouzo, C
Format Journal Article
LanguageEnglish
Published Netherlands Springer Nature B.V 01.07.1997
Subjects
Animals
Cell Differentiation - physiology
Cell Division - physiology
Cell Line
Coculture Techniques
Epithelial Cells - cytology
Gene Expression Regulation - genetics
Hematopoietic Stem Cells - cytology
Humans
Liver - cytology
Membrane Proteins - physiology
Signal Transduction - genetics
Signal Transduction - physiology
Transcription, Genetic - genetics
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Summary:The coculture, the principle of which is to restore in vitro cell-cell interaction signals present in vivo, is not only a culture model system: it also has the great advantage of mimicking the physiological situation. Indeed, the participation of proximal and/or contacting cells in the control of development and differentiation of various tissues, including liver, is now well established. It is therefore of interest to investigate further the mechanisms by which cell interactions are able to control cell differentiation and proliferation, and principally in hepatocytes.
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ISSN:0742-2091
1573-6822
DOI:10.1023/a:1007475122321