Pharmacology of Common Analgesic and Sedative Drugs Used in the Neonatal Intensive Care Unit

In this review of analgesic and sedation medication in neonates, important classes of old and newer medications commonly used in the neonatal intensive care unit setting are discussed. In addition to drug metabolism, efficacy, and safety for individual drugs, new insights into multimodal analgesic a...

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Bibliographic Details
Published inClinics in perinatology Vol. 46; no. 4; p. 673
Main Authors Donato, Jamesia, Rao, Karishma, Lewis, Tamorah
Format Journal Article
LanguageEnglish
Published United States 01.12.2019
Subjects
Analgesia
Neonatal
Pharmacology
Pain
Sedation
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Summary:In this review of analgesic and sedation medication in neonates, important classes of old and newer medications commonly used in the neonatal intensive care unit setting are discussed. In addition to drug metabolism, efficacy, and safety for individual drugs, new insights into multimodal analgesic approaches suggest ways in which multiple analgesic drug classes can be combined to maximize efficacy and minimize toxicity. Opiate pharmacogenetics and the potential for a precision therapeutics approach is explored, with a final description of gaps in knowledge and a call for future research of pain and sedation control in the neonatal population.
ISSN:1557-9840
DOI:10.1016/j.clp.2019.08.004