T-bet and Gata3 in controlling type 1 and type 2 immunity mediated by innate lymphoid cells

Highlights ► A T-bet gradient controls fate and function of CCR6− ILC3s. ► T-bet and the control of ILC-mediated immunity to infections. ► Gata3 and ILC2 cell fate. ► ILC2P, a lineage specified progenitor of ILC2s.

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Bibliographic Details
Published inCurrent opinion in immunology Vol. 25; no. 2; pp. 139 - 147
Main Authors Hoyler, Thomas, Connor, Catherine A, Kiss, Elina A, Diefenbach, Andreas
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2013
Subjects
Allergy and Immunology
Animals
GATA3 Transcription Factor - metabolism
Humans
Immunity, Innate - genetics
Immunity, Innate - immunology
T-Box Domain Proteins - metabolism
Th1 Cells - immunology
Th1 Cells - metabolism
Th2 Cells - immunology
Th2 Cells - metabolism
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Summary:Highlights ► A T-bet gradient controls fate and function of CCR6− ILC3s. ► T-bet and the control of ILC-mediated immunity to infections. ► Gata3 and ILC2 cell fate. ► ILC2P, a lineage specified progenitor of ILC2s.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2013.02.007