Salidroside rescued mice from experimental sepsis through anti-inflammatory and anti-apoptosis effects

• Published in: The Journal of surgical research Vol. 195; no. 1; pp. 277 - 283
• Main Authors: Liu, Shanshan, MD, Yu, Xiongwei, MD, Hu, Baoji, MD, Zou, Yun, MD, Li, Jinbao, MD, PhD, Bo, Lulong, MD, PhD, Deng, Xiaoming, MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2015
• Subjects: Acute Lung Injury - etiology; Acute Lung Injury - prevention & control; Animals; Apoptosis; Apoptosis - drug effects; Bacterial clearance; Cytokines - blood; Drug Evaluation, Preclinical; Experimental sepsis; Glucosides - pharmacology; Glucosides - therapeutic use; Inflammation - drug therapy; Male; Mice, Inbred C57BL; Phenols - pharmacology; Phenols - therapeutic use; Phytotherapy; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Proinflammatory response; Random Allocation; Rhodiola; Sepsis - blood; Sepsis - complications; Sepsis - drug therapy; Spleen - drug effects; Surgery; Thymus Gland - drug effects; Traditional Chinese medicine; Traditional Chinese medicine; Experimental sepsis; Proinflammatory response; Bacterial clearance; Apoptosis
• ISSN: 0022-4804; 1095-8673
• DOI: 10.1016/j.jss.2015.01.021

Abstract Background Salidroside (SDS) is the main effective component of Rhodiola rosea L with a variety of pharmacologic properties. The objective of this study was to investigate the efficacy of SDS in the treatment of experimental sepsis in mice and explore the possible underlying action mechanisms. Methods Sepsis was induced in C57BL/6 male mice via cecal ligation and puncture (CLP). The animals were divided into three groups as follows: sham, CLP, and CLP plus SDS. SDS (50 mg/kg) was injected intraperitoneally 1 h after operation. Postoperative survival of the mice, bacterial clearance in blood and peritoneal lavage fluid, cytokine secretion in blood, and histology of lung were evaluated. In addition, apoptosis of immune cells in the spleen and thymus were examined, respectively. Results SDS administration prolonged the survival of the septic mice, inhibited the proinflammatory responses, and enhanced bacterial clearance. It also alleviated the pathologic changes in the lung and inhibited the apoptosis of immune cells in the spleen and thymus after CLP challenge. Conclusions SDS exerts a protective effect in CLP-induced sepsis by attenuating the proinflammatory responses, enhancing bacterial clearance, and preserving adaptive immunity. SDS may be a promising therapeutic strategy for the treatment of sepsis.