Surgical considerations in 22Q11.2 deletion syndrome

The 22q11.2 deletion syndrome (22q11DS) may be associated with several palatal abnormalities, including overt cleft palate, submucosal cleft palate, palatopharyngeal disproportion, and velar hypotonia. The syndrome is the genetic disorder most commonly associated with velopharyngeal dysfunction (VPD...

Full description

Saved in:
Bibliographic Details
Published inClinics in plastic surgery Vol. 41; no. 2; p. 271
Main Authors Kirschner, Richard E, Baylis, Adriane L
Format Journal Article
LanguageEnglish
Published United States 01.04.2014
Subjects
Child
DiGeorge Syndrome - surgery
Humans
Oral Surgical Procedures - methods
Palate - abnormalities
Palate - surgery
Surgical Flaps
Velopharyngeal Insufficiency - surgery
22q11.2 deletion syndrome
Velocardiofacial syndrome
DiGeorge syndrome
Velopharyngeal dysfunction
Online AccessGet more information

Cover

More Information
Summary:The 22q11.2 deletion syndrome (22q11DS) may be associated with several palatal abnormalities, including overt cleft palate, submucosal cleft palate, palatopharyngeal disproportion, and velar hypotonia. The syndrome is the genetic disorder most commonly associated with velopharyngeal dysfunction (VPD). The complex causes of VPD in affected patients combine with the complexity of associated medical disorders to render surgical management of the velopharynx particularly challenging. Optimization of surgical outcomes requires precision in diagnosis, surgical management, and multidisciplinary care. This article provides an overview of 22q11DS and provides a review of the assessment and surgical management of VPD in affected individuals.
ISSN:1558-0504
DOI:10.1016/j.cps.2013.12.002