Ewing's Sarcoma / Peripheral Primitive Neuroectodermal Tumor (ES/PNET) Differentiation in Endometrial Serous Carcinomas

• Published in: Reproductive sciences (Thousand Oaks, Calif.) Vol. 16; no. 6; pp. 591 - 595
• Main Authors: Quddus, M. Ruhul, Rashid, Lanita, Sung, C. James, Steinhoff, Margaret M., Cunxian Zhang, Lawrence, W. Dwayne
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.06.2009; Springer International Publishing; Sage Publications
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Bone Neoplasms - pathology; Cell Differentiation - physiology; Cystadenocarcinoma, Serous - pathology; Diseases of the osteoarticular system; Embryology; Endometrial Neoplasms - pathology; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Humans; Medical sciences; Medicine & Public Health; Middle Aged; Neuroectodermal Tumors, Primitive, Peripheral - pathology; Obstetrics/Perinatology/Midwifery; Reproductive Medicine; Sarcoma, Ewing - pathology; Serous Membrane - pathology; Tumors; Tumors of striated muscle and skeleton; Endometrial serous carcinoma; PNET; Ewing's sarcoma; Ewing’s sarcoma; Ewing sarcoma; Gynecology; Diseases of the osteoarticular system; Malignant tumor; Obstetrics; Female genital diseases; Neuroectodermal tumor; Primitive; Serous carcinoma; Uterine diseases; Endometrium carcinoma; Differentiation; Cancer
• ISSN: 1933-7191; 1933-7205
• DOI: 10.1177/1933719109332824

The association of Ewing's sarcoma/peripheral neuroectodermal tumor and endometrioid type endometrial carcinoma has been reported relatively recently. We have recently identified Ewing's sarcoma/peripheral neuroectodermal tumor differentiation in uterine serous carcinomas and undertook this study to evaluate the frequency of both serous and endometrioid carcinomas expressing Ewing's sarcoma/peripheral neuroectodermal tumor differentiation. Seventy cases of uterine serous carcinoma were retrieved from the archival files and stained with antibodies to CD99. Positive and negative control slides were run with each staining batch. Perinuclear dot-like and/or membranous staining was regarded as positive. The frequency of Ewing's sarcoma/peripheral neuroectodermal tumor differentiation in 56 FIGO grade 3 endometrioid carcinomas was also determined and 7% uterine serous and 12.5% of FIGO grade 3 endometrioid endometrial carcinomas showed Ewing's sarcoma/peripheral neuroectodermal tumor differentiation. Given the worse prognosis associated with Ewing's sarcoma/peripheral neuroectodermal tumor differentiation, even in neoplasms already at high risk for recurrence and metastasis, a high index of suspicion for Ewing's sarcoma/peripheral neuroectodermal tumor should be maintained in high-grade uterine serous carcinomas.