Isolation of hepatitis E virus genotype 4 from patients with acute cryptogenic hepatitis in Korea

Highlights • A nested PCR method was developed for detection of HEV-3 and HEV-4. • HEV-4 isolates were identified in serum of patients with cryptogenic hepatitis. • These isolates were closely related to swine and Japanese HEV-4 strains.

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Bibliographic Details
Published inJournal of clinical virology Vol. 89; pp. 10 - 13
Main Authors Jeong, Sook-Hyang, Park, Byung-Joo, Kim, Yong-Hyun, Choi, Yun Suk, Ahn, Hee-Seop, Han, Sang-Hoon, Choi, In-Soo
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.04.2017
Subjects
Allergy and Immunology
Cluster Analysis
Cryptogenic
Genotype
Hepatitis
Hepatitis E - diagnosis
Hepatitis E - virology
Hepatitis E virus - classification
Hepatitis E virus - genetics
Hepatitis E virus - isolation & purification
Hepatitis e virus genotype 4
Humans
Infectious Disease
Korea
Phylogeny
Pigs
Polymerase Chain Reaction
Prospective Studies
Republic of Korea
RNA, Viral - analysis
RNA, Viral - genetics
Sequence Analysis, DNA
Serum - virology
cryptogenic
pigs
hepatitis
hepatitis E virus genotype 4
Korea
Pigs
Hepatitis
Cryptogenic
Hepatitis e virus genotype 4
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Summary:Highlights • A nested PCR method was developed for detection of HEV-3 and HEV-4. • HEV-4 isolates were identified in serum of patients with cryptogenic hepatitis. • These isolates were closely related to swine and Japanese HEV-4 strains.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2017.02.002