Global Dissipativity for Stochastic Genetic Regulatory Networks With Time-Delays

• Published in: IEEE access Vol. 8; pp. 34880 - 34887
• Main Authors: Wang, Lan, Dong, Yiping, Xie, Da, Cao, Jinde
• Format: Journal Article
• Language: English
• Published: Piscataway IEEE 2020; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Delays; Deoxyribonucleic acid; Disturbances; DNA; DNA chips; Field programmable gate arrays; Genetics; Global dissipativity; inequality techniques; Linear matrix inequalities; LKFs; Mathematical analysis; Mathematical model; Proteins; stochastic GRNs; Stochastic processes; Symmetric matrices
• ISSN: 2169-3536; 2169-3536
• DOI: 10.1109/ACCESS.2020.2974616

Genetic Regulatory Networks (GRNs) play an important role for the development and evolution of biological systems. On the basis of the development for DNA microarray technologies, a profound study for GRNs becomes possible at genome scale. In this article, the global dissipativity and corresponding attractive set for the GRNs with stochastic disturbances and time-delays are investigated based on Lyapunov theory. Stochastic disturbances are considered into both the feedback regulation process and the translation process for reflecting the inherent noise perturbations on a foundation of factual knowledge. Through the resort to the several appropriate Lyapunov-Krasovskii Functionals (LKFs) combining with Itô's formula and different inequality techniques, some corresponding sufficient conditions and the attractive set are obtained for the GRNs in linear matrix inequality form, which are easy to verify by the numerical software. Finally, one three-node GRN is proposed and analyzed to illustrate the validity of the proposed results by using the Field-Programmable Gate Array (FPGA) hardware simulation tool.