Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status

• Published in: Environmental research Vol. 227; p. 115697
• Main Authors: Khoury, Nadine, Martínez, María Ángeles, Paz-Graniel, Indira, Martínez-González, Miguel Ángel, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, J. Lluís, Bueno-Cavanillas, Aurora, Tur, Josep A., Sanjurjo, Sergio Cinza, Pintó, Xavier, Gaforio, José Juan, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Sayon-Orea, Carmen, Sorlí, Jose V., Pérez-Vega, Karla-Alejandra, Garcia-Rios, Antonio, Bellvert, Nuria Gómez, Gómez-Gracia, Enrique, Zulet, M.A., Chaplin, Alice, Casas, Rosa, Salcedo-Bellido, Inmaculada, Tojal-Sierra, Lucas, Bernal-Lopez, Maria-Rosa, Vázquez-Ruiz, Zenaida, Asensio, Eva M., Goday, Albert, Peña-Orihuela, Patricia J., Signes-Pastor, Antonio J., Garcia-Arellano, Ana, Fitó, Montse, Babio, Nancy, Salas-Salvadó, Jordi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.06.2023
• Subjects: Abdominal obesity; Adiposity; Cross-Sectional Studies; Dibenzofurans; Dibenzofurans, Polychlorinated - toxicity; Dioxins - analysis; Eating; Endocrine disrupting chemicals; Female; Furans; Humans; Male; Middle Aged; Obesity; Obesity, Abdominal; Overweight; Polychlorinated Biphenyls - analysis; Polychlorinated dibenzo-p-furans (PCDD/F); Polychlorinated Dibenzodioxins - toxicity; Prospective Studies; Obesity; TCDD/F; TEQ; er-MedDiet; FFQs; OR; EDC; TWI; PCDD/Fs; Endocrine disrupting chemicals; EFSA; CVD; PRs; Abdominal obesity; Adiposity; PREDIMED-Plus; MET; Polychlorinated dibenzo-p-furans (PCDD/F); WHO; BMI
• ISSN: 0013-9351; 1096-0953
• DOI: 10.1016/j.envres.2023.115697

The principal source of exposure to Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors and have been associated with different chronic diseases such as diabetes and hypertension. However, studies assessing the relationship between dietary exposure to PCDD/Fs and adiposity or obesity status in a middle-aged population are limited. To assess cross-sectionally and longitudinally the associations between estimated dietary intake (DI) of PCDD/Fs and body mass index (BMI), waist circumference, and the prevalence/incidence of obesity and abdominal obesity in a middle-aged population. In 5899 participants aged 55–75 years (48% women) living with overweight/obesity from the PREDIMED-plus cohort, PCDD/Fs DI was estimated using a 143-item validated food-frequency questionnaire, and the levels of food PCDD/F expressed as Toxic Equivalents (TEQ). Consequently, cross-sectional and prospective associations between baseline PCDD/Fs DI (in pgTEQ/week) and adiposity or obesity status were assessed at baseline and after 1-year follow-up using multivariable cox, logistic or linear regression models. Compared to participants in the first PCDD/F DI tertile, those in the highest tertile presented a higher BMI (β-coefficient [confidence interval]) (0.43kg/m2 [0.22; 0.64]; P-trend <0.001), a higher waist circumference (1.11 cm [0.55; 1.66]; P-trend <0.001), and a higher prevalence of obesity and abdominal obesity (1.05 [1.01; 1.09] and 1.02 [1.00; 1.03]; P-trend = 0.09 and 0.027, respectively). In the prospective analysis, participants in the top PCDD/F DI baseline tertile showed an increase in waist circumference compared with those in the first tertile after 1-year of follow-up (β-coefficient 0.37 cm [0.06; 0.70]; P-trend = 0.015). Higher DI of PCDD/Fs was positively associated with adiposity parameters and obesity status at baseline and with changes in waist circumference after 1-year of follow-up in subjects living with overweight/obesity. Further large prospective studies using a different population with longer follow-up periods are warranted in the future to strengthen our results. [Display omitted] •The 87% of our population exceeded the PCDD/Fs levels established by the EFSA.•Red meat, fish and seafood and fruits and vegetables contributed the most to the PCDD/F dietary intake.•Dietary intake of PCDD/Fs was associated with adiposity and obesity status at baseline.•Higher PCDD/Fs dietary intake was associated with an increase in waist circumference after 1-year of follow-up.