Effects of resistant starch on glycemic response, postprandial lipemia and appetite in subjects with type 2 diabetes

• Published in: European journal of nutrition Vol. 62; no. 5; pp. 2269 - 2278
• Main Authors: García-Vázquez, Carlos, Ble-Castillo, Jorge L., Arias-Córdova, Yolanda, Ramos-García, Meztli, Olvera-Hernández, Viridiana, Guzmán-Priego, Crystell G., Martínez-López, Mirian C., Jiménez-Domínguez, Guadalupe, Hernández-Becerra, Josafat A.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2023; Springer Nature B.V
• Subjects: Amylose; Appetite; banana starch; Blood glucose; Blood Glucose - metabolism; Chemistry; Chemistry and Materials Science; corn starch; Cross-Over Studies; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2; digestible carbohydrates; glycemic control; glycemic effect; Humans; hunger; hyperlipidemia; Hyperlipidemias; Insulin; noninsulin-dependent diabetes mellitus; Nutrition; Original Contribution; Postprandial lipemia; Postprandial Period; resistant starch; Resistant Starch - pharmacology; Satiety; Starch; Starch - metabolism; Appetite; Postprandial lipemia; Resistant starch; Glycemic response
• ISSN: 1436-6207; 1436-6215; 1436-6215
• DOI: 10.1007/s00394-023-03154-4

Purpose Resistant starch (RS) content has exhibited beneficial effects on glycemic control; however, few studies have investigated the effects of this substance on postprandial responses and appetite in subjects with type 2 diabetes (T2D). Here, we aimed to examine the effects of RS from two sources on glycemic response (GR), postprandial lipemia, and appetite in subjects with T2D. Methods In a randomized and crossover study, 17 subjects with T2D consumed native banana starch (NBS), high-amylose maize starch (HMS) or digestible maize starch (DMS) for 4 days. On day 5, a 6-h oral meal tolerance test (MTT) was performed to evaluate glycemic and insulinemic responses as well as postprandial lipemia. Besides, subjective appetite assessment was measured using a visual analogue scale. Results NBS induced a reduction on fasting glycemia, glycemia peak and insulinemic response during MTT. However, no modifications on postprandial lipemia were observed after RS treatments. Both NBS and HMS reduced hunger and increased satiety. Conclusion NBS supplementation induced more beneficial effects on glycemic metabolism than HMS even when all interventions were matched for digestible starch content. RS intake did not modify postprandial lipemia, however, positively affected subjective appetite rates. Trial registration : This trial was retrospectively registered at www.anzctr.org.au (ACTRN12621001382864) on October 11, 2021.