Determination of Serum Zinc and Phosphorus Levels in Patients with Hypothyroidism

• Published in: Biological trace element research Vol. 202; no. 7; pp. 3018 - 3024
• Main Authors: Patel, Amrendra Mani, Khan, Saba, Inam, Ahmad Merajul Hasan, Alam, Roshan, Khan, Mohammad Mustufa
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2024; Springer Nature B.V
• Subjects: Adult; Biochemistry; Biomedical and Life Sciences; Biotechnology; blood serum; Body Mass Index; Body size; Case-Control Studies; Female; Hormones; Humans; Hypothyroidism; Hypothyroidism - blood; Life Sciences; Male; Middle Aged; Nutrition; Oncology; Phosphorus; Phosphorus - blood; Regression analysis; Statistical analysis; Thyroid; Thyroid gland; Thyroid hormones; Thyroid-stimulating hormone; Thyrotropin - blood; Thyroxine; Thyroxine - blood; Triiodothyronine; Triiodothyronine - blood; Zinc; Zinc - blood; Serum phosphorus; Hypothyroidism; Serum zinc; A case–control study
• ISSN: 0163-4984; 1559-0720; 1559-0720
• DOI: 10.1007/s12011-023-03905-8

   Various studies reported that serum zinc (Zn) and phosphorus (P) levels altered in patients with hypothyroidism and vice versa, but results were found inconsistent. It was aimed to find the association between serum Zn and P in patients with hypothyroidism. In this case–control study, a total of 100 subjects (50 newly diagnosed patients of hypothyroidism and 50 controls) were enrolled aged between 25 and 60 years. Biochemical parameters such as thyroid profile, serum Zn, and P were estimated in each subject. A p  < 0.05 was considered statistically significant. The mean level of body mass index (BMI), thyroid-stimulating hormone (TSH), and serum P was found significantly elevated in cases compared to controls ( p  < 0.001). However, the mean level of total triiodothyronine (T3), thyroxine (T4), and serum Zn was found significantly reduced in cases compared to controls ( p  < 0.001). The serum Zn has shown a significant negative correlation with T3 and BMI among cases ( r  =  − 0.313 p  < 0.05, r  =  − 0.338 p  < 0.05, respectively). However, serum P has shown a significant positive correlation with TSH and BMI among cases ( r  = 0.310 p  < 0.05, r  = 0.449 p  < 0.01, respectively). Regression analysis indicated that serum Zn significantly predicted hypothyroidism ( p  < 0.00). Similarly, serum P significantly predicted hypothyroidism ( p  < 0.007). Results showed that serum Zn levels were significantly reduced and serum P levels were significantly elevated in cases compared to controls. The serum Zn and serum P both significantly associated with hypothyroidism.