Use of Buprenorphine in treatment of refractory depression—A review of current literature

Highlights • For treatment resistant depression, augmentation strategies may improve outcome in some, leaving many with disabling and distressing residual symptoms. • Based on the endogenous opioid system literature, Buprenorphine displays a rapid acting antidepressant effect at low doses. • Bupreno...

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Bibliographic Details
Published inAsian journal of psychiatry Vol. 26; pp. 94 - 98
Main Authors Stanciu, Cornel N, Glass, Oliver M, Penders, Thomas M
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.04.2017
Subjects
Analgesics, Opioid - therapeutic use
Antidepressive Agents - therapeutic use
Buprenorphine
Buprenorphine - therapeutic use
Depressive Disorder, Treatment-Resistant - drug therapy
Humans
Internal Medicine
Psychiatry
Treatment Outcome
Treatment resistant depression
Buprenorphine
Treatment resistant depression
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Summary:Highlights • For treatment resistant depression, augmentation strategies may improve outcome in some, leaving many with disabling and distressing residual symptoms. • Based on the endogenous opioid system literature, Buprenorphine displays a rapid acting antidepressant effect at low doses. • Buprenorphine is well tolerated and although further studies are needed, the limited evidence shows it could be of benefit to patients with treatment resistant depression or those intolerant to conventional standard of care.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1876-2018
1876-2026
DOI:10.1016/j.ajp.2017.01.015