sLRP1’in up retinol keeps the gut SAAfe

Retinol is shuttled to myeloid cells for conversion to retinoic acid, but the receptor facilitating uptake of SAA:retinol complexes on myeloid cells is unknown. In a recent issue of Science, Bang et al. (2021) use genetic and biochemical approaches to reveal this critical receptor to be LRP1 and sho...

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Bibliographic Details
Published inImmunity (Cambridge, Mass.) Vol. 54; no. 11; pp. 2447 - 2449
Main Authors Labuda, Jasmine, Harrison, Oliver J.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 09.11.2021
Subjects
Carrier Proteins
Tretinoin - metabolism
Vitamin A - metabolism
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Summary:Retinol is shuttled to myeloid cells for conversion to retinoic acid, but the receptor facilitating uptake of SAA:retinol complexes on myeloid cells is unknown. In a recent issue of Science, Bang et al. (2021) use genetic and biochemical approaches to reveal this critical receptor to be LRP1 and show that this axis is essential for intestinal innate and adaptive immune responses. Retinol is shuttled to myeloid cells for conversion to retinoic acid, but the receptor facilitating uptake of SAA:retinol complexes on myeloid cells is unknown. In a recent issue of Science, Bang et al. (2021) use genetic and biochemical approaches to reveal this critical receptor to be LRP1 and show that this axis is essential for intestinal innate and adaptive immune responses.
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ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2021.10.013