Living Related Liver Transplantation. Why This Option Has Been Discarded in a Pediatric Liver Transplant Program in Chile

• Published in: Transplantation proceedings Vol. 37; no. 8; pp. 3378 - 3379
• Main Authors: Uribe, M., Buckel, E., Ferrario, M., Godoy, J., González, G., Ceresa, S., Hunter, B., Cavallieri, S., Berwart, F., Blanco, Á., Smok, G., Calabrán, L., Herzog, C., Santander, M.T.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01.10.2005; Elsevier Science
• Subjects: Attitude to Health; Biological and medical sciences; Child; Family; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Graft Rejection - epidemiology; Humans; Liver Transplantation - statistics & numerical data; Living Donors - psychology; Living Donors - statistics & numerical data; Living Donors - supply & distribution; Medical sciences; Retrospective Studies; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tissue, organ and graft immunology; Treatment Outcome; South America; Chile; America; Human; Pediatrics; Program; Digestive system; Living donor; Liver; Related donor; Transplantation; Homotransplantation; Medicine; Treatment; Surgery; Graft; Child
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2005.09.097

Living related living transplantation (LRLT) has opened new possibilities for planning transplantation in better conditions for children with emergency situations and chronic liver diseases. Since we began the LRLT program in 1999, we have performed 57 pediatric liver transplants, 17 (29.8%) using living related donors (LRD). The aim of this study was to analyze the reasons why LRD were discarded as a therapeutic option. All pediatric patients were prospectively included in our Microsoft Excel database that was reviewed for obtaining information about causes why the LRLT could not be done. LRLT was proposed in 28 cases and performed in 17 (60.7%). The reasons for LRD rejection were: parent’s fear of surgical complications in four cases; drug abuse in two; a mother without family support; medical reasons in two; and only one, due to anatomical reasons and in one case, cadaveric graft transplantation was performed while completing the father’s evaluation. From these eleven cases, the indications for liver transplant were acute liver failure (ALF) in seven, biliary atresia in three, and Alagille syndrome in one. Nine were transplanted with cadaveric organs, but two patients with ALF died awaiting a liver. Efforts should be made to clarify the advantages and the disadvantages of LRD in each case, allowing parents to make a free, well-informed decision.