Effect of tunable redox behavior of bis chelate substituted 1,10-phenantroline Cu(II) complexes on its reaction with superoxide anion in DMSO. Toward a simple criterion to identify a SOD-like mechanism

• Published in: Journal of inorganic biochemistry Vol. 175; pp. 118 - 128
• Main Authors: Manzanera-Estrada, Mayra E., Cruz-Ramírez, Marisela, Flores-Alamo, Marcos, Gracia y Jiménez, José Miguel, Galindo-Murillo, Rodrigo, García-Ramos, Juan Carlos, Ruiz-Azuara, Lena, Ortiz-Frade, Luis
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2017
• Subjects: Biomimetic metal complexes; Chelating Agents - chemical synthesis; Chelating Agents - chemistry; Copper (II)-1,10-phenantroline complexes; Copper - chemistry; Dimethyl Sulfoxide - chemistry; Electrochemistry; Phenanthrolines - chemistry; SOD-like mechanism; Superoxide Dismutase; Superoxides - chemistry; SOD-like mechanism; Electrochemistry; Biomimetic metal complexes; Copper (II)-1,10-phenantroline complexes
• ISSN: 0162-0134; 1873-3344
• DOI: 10.1016/j.jinorgbio.2017.07.013

In this work we report a series of Cu(II) complexes [Cu(N-N)2(X)]+, (N-N=substituted 1,10-phenanthroline derivatives and X=Cl− or NO3−), with tunable E1/2 for electrochemical reduction [CuII(N-N)2(X)]++1e−⇌[CuI(N-N)2]+X−. The disproportion of O2•− was explored in presence of the electro-generated species [CuI(N-N)2]+ using cyclic voltammetry in a non-aqueous media, arising a new simple method to propose a SOD-like mechanism, which can be used as a quick guide test for a compound, before being proven in biological assays. It was found that complexes with high negative half wave potential values (E1/2) for Cu(II)/Cu(I) couple shown a current increment for oxygen reduction, related to the capability of the disproportion of this reactive oxygen species. Tunable half wave potential (E1/2) Cu(II) complexes, were used to study the disproportion of O2•− by the electrogenerated Cu(I)species in DMSO, as a quick guide test for a compound, before being proven in biological assays. [Display omitted] •Cu(II) complexes with substituted 1,10-phenanthroline presented tunable (E1/2).•Cyclic voltammetry was used to study O2•− disproportion by electro-generated Cu(I) species.•More negative E1/2 for the Cu(II)/Cu(I) couple increased O2•− disproportion in DMSO.•A relationship between (E1/2) and the ratio of currents (iO2CuL2/iO2) was obtained.