Effect of tunable redox behavior of bis chelate substituted 1,10-phenantroline Cu(II) complexes on its reaction with superoxide anion in DMSO. Toward a simple criterion to identify a SOD-like mechanism
In this work we report a series of Cu(II) complexes [Cu(N-N)2(X)]+, (N-N=substituted 1,10-phenanthroline derivatives and X=Cl− or NO3−), with tunable E1/2 for electrochemical reduction [CuII(N-N)2(X)]++1e−⇌[CuI(N-N)2]+X−. The disproportion of O2•− was explored in presence of the electro-generated sp...
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Published in | Journal of inorganic biochemistry Vol. 175; pp. 118 - 128 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.10.2017
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Subjects | |
Online Access | Get full text |
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Summary: | In this work we report a series of Cu(II) complexes [Cu(N-N)2(X)]+, (N-N=substituted 1,10-phenanthroline derivatives and X=Cl− or NO3−), with tunable E1/2 for electrochemical reduction [CuII(N-N)2(X)]++1e−⇌[CuI(N-N)2]+X−. The disproportion of O2•− was explored in presence of the electro-generated species [CuI(N-N)2]+ using cyclic voltammetry in a non-aqueous media, arising a new simple method to propose a SOD-like mechanism, which can be used as a quick guide test for a compound, before being proven in biological assays. It was found that complexes with high negative half wave potential values (E1/2) for Cu(II)/Cu(I) couple shown a current increment for oxygen reduction, related to the capability of the disproportion of this reactive oxygen species.
Tunable half wave potential (E1/2) Cu(II) complexes, were used to study the disproportion of O2•− by the electrogenerated Cu(I)species in DMSO, as a quick guide test for a compound, before being proven in biological assays. [Display omitted]
•Cu(II) complexes with substituted 1,10-phenanthroline presented tunable (E1/2).•Cyclic voltammetry was used to study O2•− disproportion by electro-generated Cu(I) species.•More negative E1/2 for the Cu(II)/Cu(I) couple increased O2•− disproportion in DMSO.•A relationship between (E1/2) and the ratio of currents (iO2CuL2/iO2) was obtained. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0162-0134 1873-3344 |
DOI: | 10.1016/j.jinorgbio.2017.07.013 |