THRESHOLD CONCENTRATION OF NITROUS OXIDE AFFECTING PSYCHOMOTOR PERFORMANCE

Using audiovisual reaction times, no effects were found in 12 subjects exposed to 1, 2, 4, or 8% nitrous oxide. In subsequent studies on 30 subjects, a positive effect on performance was found at a concentration of between 8 and 12% nitrous oxide. In addition, there was no difference in mean reactio...

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Published inBritish journal of anaesthesia : BJA Vol. 51; no. 3; pp. 177 - 180
Main Authors ALLISON, R.H., SHIRLEY, A.W., SMITH, G.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.03.1979
Oxford University Press
Subjects
Adult
Dose-Response Relationship, Drug
Humans
Nitrous Oxide - pharmacology
Reaction Time - drug effects
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Summary:Using audiovisual reaction times, no effects were found in 12 subjects exposed to 1, 2, 4, or 8% nitrous oxide. In subsequent studies on 30 subjects, a positive effect on performance was found at a concentration of between 8 and 12% nitrous oxide. In addition, there was no difference in mean reaction time in 12 subjects exposed to air or 8% nitrous oxide. It is concluded that the threshold concentration of nitrous oxide for an effect on psychomotor performance as assessed by choice reaction times probably lies between 8 and 12%.
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content type line 23
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/51.3.177