Effects of heavy-atom substituents on matrices used for matrix-assisted laser desorption-ionization mass spectrometry

The data reported show that heavy-atom substitution on matrices that are used for matrix-assisted laser desorption-ionization mass spectrometry enhance [M + H] + ion yields of both Leu-enkephalin and vitamin B 12. Heavy-atom substitution alters the excited state relaxation dynamics of the matrices a...

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Published inJournal of the American Society for Mass Spectrometry Vol. 5; no. 9; pp. 800 - 806
Main Authors Preston-Schaffter, Lisa M., Kinsel, Gary R., Russell, D.H.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.1994
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Summary:The data reported show that heavy-atom substitution on matrices that are used for matrix-assisted laser desorption-ionization mass spectrometry enhance [M + H] + ion yields of both Leu-enkephalin and vitamin B 12. Heavy-atom substitution alters the excited state relaxation dynamics of the matrices as indicated by measured decreases in the measured luminescence (fluorescence and/or phosphorescence) observed for heavy atoms that contain matrices relative to the nonheavy-atom-substituted matrices. The results presented are consistent with the direct involvement of an electronically excited state of the matrix in the formation of analyte [M + H] + ions.
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ISSN:1044-0305
1879-1123
DOI:10.1016/1044-0305(94)87002-0