High-molecular-weight HPMA-based polymer drug carriers for delivery to tumor

In this work, design and synthesis of high-molecular-weight N-(2-hydroxypropyl)methacrylamide-based polymer drug delivery systems tailored for cancer therapy is summarized. Moreover, the influence of their architecture on tumor accumulation and in vivo anti-cancer efficacy is discussed. Mainly, the...

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Bibliographic Details
Published inPhysiological research Vol. 65; no. Suppl 2; pp. S179 - S190
Main Authors Kostka, L, Etrych, T
Format Journal Article
LanguageEnglish
Published Czech Republic Institute of Physiology 01.01.2016
Subjects
Antineoplastic Agents
Aqueous solutions
Drug Carriers
Drug delivery systems
Drugs
Methacrylates
Micelles
Nanoparticles
Permeability
Polymers
Prodrugs
Tumors
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Summary:In this work, design and synthesis of high-molecular-weight N-(2-hydroxypropyl)methacrylamide-based polymer drug delivery systems tailored for cancer therapy is summarized. Moreover, the influence of their architecture on tumor accumulation and in vivo anti-cancer efficacy is discussed. Mainly, the high-molecular-weight delivery systems, such as branched, grafted, multi-block, star-like or micellar systems, with molecular weights greater than the renal threshold are discussed and reviewed in detail.
ISSN:0862-8408
1802-9973
DOI:10.33549/physiolres.933420