Development of a dual-cure mineral trioxide aggregate-based cement: Biological, physical, and mechanical properties

• Published in: Journal of conservative dentistry Vol. 21; no. 1; pp. 74 - 79
• Main Authors: Pintado, Laura, Torre, Eliana, Santos Selayaran, Maicon, de Carvalho, Rodrigo, Zanchi, Cesar, Manzolli Leite, Fábio, Etges, Adriana
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.01.2018; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd
• Subjects: Analysis; Analysis of variance; Biocompatibility; Care and treatment; Cell culture; Cell lines; Cement; Cytotoxicity; Data processing; Dental pulp; Dental restorative materials; Dentin; Dentistry; Fibroblasts; Genotoxicity; Kruskal-Wallis test; Light; Mechanical properties; Original; Polymerization; Properties; Semiotics; Sulfur trioxide; Brazil; Denmark; United States > US; Aarhus Denmark; toxicity; tensile strength; Mineral trioxide aggregate; pulp capping and pulpectomy agents; surfactant
• ISSN: 0972-0707; 0974-5203
• DOI: 10.4103/JCD.JCD_393_16

Purpose: The purpose of this study is to compare the physical, mechanical, and biocompatibility properties of a new dual-cure white mineral trioxide aggregate (D-W-MTA) and a commercial W-MTA. Materials and Methods: Diametral tensile strength (DTS), water sorption (WSp), and water solubility (WSl) tests were performed. Cytotoxicity was observed in primary culture of human pulp fibroblasts (HPFs) and mouse 3T3/NIH fibroblast lineage. Specimens of both materials were embedded in 1 mL of Dulbecco's modified essential medium for 24 h. Cells were incubated for 24 h with the eluates. Cytotoxicity was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and genotoxicity by micronucleus (MN) formation. Data were analyzed by ANOVA and Kruskal-Wallis tests considering P < 0.05. Results: D-MTA and W-MTA not showed cytotoxic effect on the two cell lines. However, D-MTA stimulated HPF growth. The MN count was similar to that of the control group for D-MTA and W-MTA. D-MTA presented lower DTS and WSl. Nevertheless, WSp was similar in the two groups. Conclusion: The results suggest that D-MTA is a promising material for pulp capping. Thus, in vivo tests should be performed to evaluate the performance of this material.