Host-Guest Inclusion Complexes of Natural Products and Nanosystems: Applications in the Development of Repellents

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 8; p. 2519
• Main Authors: Pena, Gueive Astur, da Costa Lopes, Anna Sylmara, de Morais, Sylvano Heleno Salgado, do Nascimento, Lidiane Diniz, Dos Santos, Fábio Rogério Rodrigues, da Costa, Kauê Santana, Alves, Cláudio Nahum, Lameira, Jerônimo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.04.2022; MDPI
• Subjects: Arthropods; Bioactive compounds; Biocompatibility; Biological Products - pharmacology; Controlled release; Delayed-Action Preparations; Environmental protection; Essential oils; Inclusion complexes; Insect Repellents - chemistry; Insect Repellents - pharmacology; Insects; intermolecular interactions; Lipids; Mosquitoes; nanoencapsulation; nanosystems; Natural products; natural repellents; Nature conservation; Oils & fats; Oils, Volatile - chemistry; Oils, Volatile - pharmacology; Organic chemistry; Pheromones; Polymers; Proteins; Repellents; Review; Shelf life; Supramolecular compounds; Thermal stability; Toxicity; Vectors; VOCs; Volatile organic compounds; United States > US; natural repellents; nanoencapsulation; controlled release; intermolecular interactions; nanosystems; essential oils
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27082519

Repellents are compounds that prevent direct contact between the hosts and the arthropods that are vectors of diseases. Several studies have described the repellent activities of natural compounds obtained from essential oils. In addition, these chemical constituents have been pointed out as alternatives to conventional synthetic repellents due to their interesting residual protection and low toxicity to the environment. However, these compounds have been reported with short shelf life, in part, due to their volatile nature. Nanoencapsulation provides protection, stability, conservation, and controlled release for several compounds. Here, we review the most commonly used polymeric/lipid nanosystems applied in the encapsulation of small organic molecules obtained from essential oils that possess repellent activity, and we also explore the theoretical aspects related to the intermolecular interactions, thermal stability, and controlled release of the nanoencapsulated bioactive compounds.