Prenatal ultrasound and magnetic resonance imaging in fetal varicella syndrome: correlation with pathology findings

• Published in: Prenatal diagnosis Vol. 23; no. 9; pp. 705 - 709
• Main Authors: Verstraelen, Hans, Vanzieleghem, Bart, Defoort, Paul, Vanhaesebrouck, Piet, Temmerman, Marleen
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.09.2003; Wiley
• Subjects: Abnormalities, Multiple - diagnosis; Abnormalities, Multiple - diagnostic imaging; Abnormalities, Multiple - pathology; Adult; Biological and medical sciences; Chickenpox - diagnosis; Chickenpox - diagnostic imaging; Chickenpox - pathology; congenital anomalies; Diagnosis, Differential; Fatal Outcome; Female; Fetal Diseases - diagnosis; Fetal Diseases - diagnostic imaging; Fetal Diseases - pathology; fetal varicella syndrome; Gynecology. Andrology. Obstetrics; Human viral diseases; Humans; Infant, Newborn; Infectious diseases; Magnetic Resonance Imaging; Male; Management. Prenatal diagnosis; Medical sciences; Miscellaneous; Pregnancy; Pregnancy Trimester, Second; Pregnancy. Fetus. Placenta; prenatal magnetic resonance imaging; prenatal ultrasound; Ultrasonography, Prenatal; Varicella-zoster virus; Viral diseases; Sonography; Human; prenatal magnetic resonance imaging; prenatal ultrasound; congenital anomalies; Nuclear magnetic resonance imaging; Infection; Case study; Prenatal; Autopsy; Viral disease; Echography; Varicella; Fetus; Diagnosis; fetal varicella syndrome
• ISSN: 0197-3851; 1097-0223
• DOI: 10.1002/pd.669

Objectives To assess the diagnostic value of prenatal magnetic resonance imaging (MRI) in addition to prenatal ultrasound in a case of fetal varicella syndrome. Methods Comparison of prenatal ultrasound and MRI features obtained at 26 and 32 weeks, respectively, with neonatal imaging (ultrasound, MRI and CT) and macroscopic and microscopic pathology findings in a fatal case of varicella embryopathy. Results Prenatal ultrasound correlated fairly well with neonatal imaging and pathology findings. Most lesions of thoracic, abdominal and retroperitoneal viscera, limb involvement and even dermatologic features were apparent on ultrasonography. Involvement of the CNS, including cerebellar hypoplasia, was not apparent on ultrasound examination, but was clearly demonstrated by prenatal MRI. Conclusion If maternal seroconversion for the varicella‐zoster virus is suspected, combining prenatal ultrasound and magnetic resonance imaging may document the extent of tissue damage in fetal varicella syndrome to a larger extent than has been reported until now and therefore contribute to due counselling following maternal varicella exposure. Copyright © 2003 John Wiley & Sons, Ltd.