Immunohistochemical detection of cytokines in tissues of Aotus monkeys infected with hepatitis A virus

Cytokines IL-1-beta, IL-2, and TNF alpha were detected in occasional cells within portal inflammatory infiltrates beginning 3 weeks after oral inoculation of monkeys with HAV. The number of cells secreting those cytokines did not increase, and they were not of importance in the pathogenesis. Product...

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Bibliographic Details
Published inAnnals of the New York Academy of Sciences Vol. 730; p. 318
Main Authors Polotsky, Y E, Vassell, R A, Binn, L N, Asher, L V
Format Journal Article
LanguageEnglish
Published United States 01.09.1994
Subjects
Animals
Aotus trivirgatus
Cytokines - metabolism
Hepatitis A - immunology
Immunoenzyme Techniques
T-Lymphocyte Subsets - immunology
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Summary:Cytokines IL-1-beta, IL-2, and TNF alpha were detected in occasional cells within portal inflammatory infiltrates beginning 3 weeks after oral inoculation of monkeys with HAV. The number of cells secreting those cytokines did not increase, and they were not of importance in the pathogenesis. Production of cytokines IL-6 and IL-4 by T lymphocytes infiltrating portal areas started 4 weeks after inoculation, stimulating local expansion of B cells, probably secreting antibodies to HAV. IL-6 and IL-4 may also stimulate cytotoxic activity of a few CD8+ lymphocytes.
ISSN:0077-8923
DOI:10.1111/j.1749-6632.1994.tb44279.x