In Vitro Anticancer and Radiosensitizing Activities of Phlorethols from the Brown Alga Costaria costata

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 14; p. 3208
• Main Authors: Malyarenko, Olesya S, Imbs, Tatiana I, Ermakova, Svetlana P
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.07.2020; MDPI
• Subjects: Algae; anticancer activity; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Biological Products - chemistry; Biological Products - isolation & purification; Biological Products - pharmacology; Breast cancer; Cancer therapies; Cell Line, Tumor; Cell Survival - drug effects; Colon; Colon cancer; Colonic Neoplasms; Colorectal cancer; Colorectal carcinoma; Communication; Costaria costata; Cytotoxicity; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Humans; Hypotheses; Investigations; Irradiation; Melanoma; Penicillin; Phaeophyceae - chemistry; phlorethols; phlorotannins; Polymerization; Polymers; Polyphenols; Radiation effects; Radiation therapy; Radiation-Sensitizing Agents - chemistry; Radiation-Sensitizing Agents - isolation & purification; Radiation-Sensitizing Agents - pharmacology; radiosensitizer; Radiosensitizers; radiotherapy; X ray irradiation; United States > US; radiotherapy; colorectal cancer; anticancer activity; radiosensitizer; phlorethols; phlorotannins
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules25143208

The anticancer and radiosensitizing effects of high-molecular-weight phlorethols (Mw = 2520 Da) isolated from the brown algae of on human colorectal carcinoma HCT 116 and HT-29 cells were investigated. Phlorethols possessed cytotoxic activity against HT-29 (IC = 92 μg/mL) and HCT 116 (IC = 94 μg/mL) cells. at non-toxic concentrations inhibited the colony formation in colon cancer cells and significantly enhanced their sensitivity to low non-toxic X-ray irradiation. The combinatory effect of radiation and was synergistic (Combination index < 0.7). Algal phlorethols might be prospective candidates as radiosensitizers to improve the scheme of radiotherapy.