Asthma: comparative bronchodilator effects of ipratropium bromide and isoproterenol

The effect of ipratropium bromide administered at two dosage levels, 40 and 80 mug, isoproterenol, 150 mug, and placebo using a metered dose inhaler was evaluated in ten adult patients with asthma in a double-blind, crossover study. The new atropine-like drug proved to be as effective a bronchodilat...

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Bibliographic Details
Published inJournal of clinical pharmacology Vol. 16; no. 4; p. 198
Main Authors Yeager, Jr, H, Weinberg, R M, Kaufman, L V, Katz, S
Format Journal Article
LanguageEnglish
Published England 01.04.1976
Subjects
Adult
Airway Resistance
Asthma - drug therapy
Asthma - physiopathology
Atropine Derivatives
Clinical Trials as Topic
Female
Forced Expiratory Volume
Humans
Ipratropium - therapeutic use
Isoproterenol - therapeutic use
Male
Maximal Expiratory Flow-Volume Curves
Maximal Midexpiratory Flow Rate
Middle Aged
Time Factors
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Summary:The effect of ipratropium bromide administered at two dosage levels, 40 and 80 mug, isoproterenol, 150 mug, and placebo using a metered dose inhaler was evaluated in ten adult patients with asthma in a double-blind, crossover study. The new atropine-like drug proved to be as effective a bronchodilator as isoproterenol in this study, although it had a later peak effect. Ipratropium bromide had a longer course of action than isoproterenol (4 hours compared to 1-2 hours) and was free of significant side effects. The larger dose of the new drug produced a slightly greater and longer-acting effect than the smaller dose. Ipratropium bromide seems to have had bronchodilator effects on both large and small airways.
ISSN:0091-2700
DOI:10.1002/j.1552-4604.1976.tb01518.x