Dietary fat modifies the postprandial inflammatory state in subjects with metabolic syndrome: the LIPGENE study

• Published in: Molecular nutrition & food research Vol. 56; no. 6; pp. 854 - 865
• Main Authors: Cruz-Teno, Cristina, Pérez-Martínez, Pablo, Delgado-Lista, Javier, Yubero-Serrano, Elena M., García-Ríos, Antonio, Marín, Carmen, Gómez, Purificación, Jiménez-Gómez, Yolanda, Camargo, Antonio, Rodríguez-Cantalejo, Fernando, Malagón, Maria M., Pérez-Jiménez, Francisco, Roche, Helen M., López-Miranda, José
• Format: Journal Article
• Language: English
• Published: Weinheim Blackwell Publishing Ltd 01.06.2012; Wiley
• Subjects: Biological and medical sciences; Cohort Studies; Diet, Fat-Restricted; Diet, High-Fat - adverse effects; Dietary Fats - administration & dosage; Dietary Fats - adverse effects; Dietary Fats - therapeutic use; Fatty Acids, Monounsaturated - administration & dosage; Fatty Acids, Monounsaturated - therapeutic use; Fatty Acids, Omega-3 - administration & dosage; Fatty Acids, Omega-3 - therapeutic use; Female; Food industries; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation; Humans; Inflammation; Leukocytes, Mononuclear - metabolism; Male; Matrix Metalloproteinase 9 - blood; Matrix Metalloproteinase 9 - genetics; Matrix Metalloproteinase 9 - metabolism; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - diet therapy; Metabolic Syndrome - immunology; Metabolic Syndrome - metabolism; Middle Aged; Monounsaturated fatty acids; NF-kappa B - blood; NF-kappa B - genetics; NF-kappa B - metabolism; NF-kB; Patient Compliance; Postprandial Period; Postprandial state; RNA, Messenger - metabolism; Transcription Factor RelA - blood; Tumor Necrosis Factor-alpha - blood; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; Postprandial state; Monounsaturated fatty acids; Postprandial; NF-kB; Monounsaturated fatty acid; Fat; Lipids; Inflammation; Metabolism; Metabolic syndrome
• ISSN: 1613-4125; 1613-4133; 1613-4133
• DOI: 10.1002/mnfr.201200096

Scope Our aim was to investigate whether the inflammatory state associated to metabolic syndrome (MetS) patients is affected by diets with different fat quality and quantity. Methods and results Seventy‐five subjects from LIPGENE cohort were included in this feeding trial and randomly assigned to one of four diets: high saturated fatty acids (HSFA); high monounsaturated fatty acids (HMUFA) and two low‐fat, high complex carbohydrate (LFHCC) diets, supplemented with long‐chain n‐3 polyunsaturated fatty acids (LFHCC n‐3) or placebo (LFHCC), for 12 weeks each. A postprandial fat challenge, reflecting the intervention dietary fat composition, was conducted post‐intervention. The HMUFA diet significantly reduced postprandial nuclear transcription factor‐kappaB (NF‐kB) activity and the nuclear p65 protein levels relative to fasting values (p < 0.05). Furthermore, we observed a postprandial decrease in this protein with the HMUFA diet compared with the HSFA and LFHCC diets (p < 0.05). The postprandial response of inhibitory molecule from NF‐kB mRNA levels increased with the HMUFA diet compared with the HSFA and LFHCC n‐3 diets (p < 0.05). Postprandial tumor necrosis factor‐α and Metalloproteinase 9 mRNA levels were also reduced after the HMUFA diet compared with the HSFA diet (p < 0.05). Conclusion Our results indicate that the long‐term consumption of a healthy diet model with HMUFA attenuates the postprandial inflammatory state associated with MetS.