A study of the relationship between brachial artery vasodilation and platelet/lymphocyte ratio in diabetic patients with coronary atherosclerosis

• Published in: Journal of clinical laboratory analysis Vol. 37; no. 9-10; pp. e24935 - n/a
• Main Authors: Wang, Meiling, Liu, Yanjie, Zhang, Lei, Chen, Li, Zhao, Wei, Zhang, Hebin, Wu, Hao
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.05.2023; John Wiley and Sons Inc
• Subjects: Arteriosclerosis; Atherosclerosis; Blood platelets; Blood pressure; Body mass index; Calcification; Calcification (ectopic); Cardiovascular disease; Cell number; Computed tomography; Coronary artery; coronary artery calcification; Coronary vessels; Diabetes; Diabetes mellitus; endothelial function; Endothelium; Heart rate; Hypertension; Lipoproteins; Lymphocytes; Medical imaging; Peripheral blood; Platelets; platelet‐lymphocyte ratio; Regression analysis; Software; type 2 diabetes; Vasodilation; Vein & artery diseases; endothelial function; type 2 diabetes; coronary artery calcification; platelet-lymphocyte ratio; vasodilation
• ISSN: 0887-8013; 1098-2825
• DOI: 10.1002/jcla.24935

Background To investigate the correlation between brachial artery flow‐mediated endothelium‐dependent dilation (FMD) and platelet–lymphocyte ratio (PLR) in peripheral blood and coronary atherosclerosis in diabetic patients. Methods Seventy‐five diabetic patients aged 62 ± 9 years, 68% male and 32% female, who underwent brachial artery endothelial function test and coronary CT scan were collected. Coronary artery calcification (CAC) was observed to assess the presence of coronary atherosclerosis, and high‐resolution extravascular ultrasound was used to detect FMD. Platelet count and lymphocyte count were recorded by routine blood tests, and PLR was calculated for each study subject. Statistical methods were used to verify the association of FMD and PLR with CAC assessed by CT, respectively. Results Patients with coronary atherosclerosis had decreased FMD and increased PLR compared with patients with normal coronary arteries. Univariate logistic regression analysis showed that CAC score was significantly associated with both FMD (odds ratio: 0.167; 95% confidence interval: 0.049–0.565; p = 0.002) and PLR (odds ratio: 0.127; 95% confidence interval: 0.033–0.484; p = 0.001) at FMD < 5.1% or PLR > 130. The area under the ROC curve of FMD and PLR alone was 0.760 and 0.763, respectively. In addition, combined diagnosis of FMD and PLR showed the highest area under the ROC curve (0.830). Conclusion FMD combined with PLR is expected to be a precise diagnostic modality for coronary artery calcification in diabetic patients. ROC curve of single and combined diagnostic modalities of FMD and PLR in the diagnosis of coronary artery calcification.