Cerebral Blood Flow Hemispheric Asymmetry in Comatose Adults Receiving Extracorporeal Membrane Oxygenation

• Published in: Frontiers in neuroscience Vol. 16; p. 858404
• Main Authors: Johnson, Thomas W, Dar, Irfaan A, Donohue, Kelly L, Xu, Yama Y, Santiago, Esmeralda, Selioutski, Olga, Marinescu, Mark A, Maddox, Ross K, Wu, Tong Tong, Schifitto, Giovanni, Gosev, Igor, Choe, Regine, Khan, Imad R
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 11.04.2022; Frontiers Media S.A
• Subjects: Asymmetry; Blood flow; Blood pressure; Brain injury; Cerebral blood flow; Cerebral hemispheres; cerebrovascular autoregulation; Coma; Congestive heart failure; Design; diffuse correlation spectroscopy; Extracorporeal membrane oxygenation; Femoral artery; Flow velocity; Hemispheric laterality; Injuries; Neuroimaging; Neuroscience; Oxygenation; Patients; Perfusion; Spectroscopy; Spectrum analysis; Time series; United States > US; cerebral blood flow; cerebrovascular autoregulation; extracorporeal membrane oxygenation; diffuse correlation spectroscopy; coma
• ISSN: 1662-4548; 1662-453X; 1662-453X
• DOI: 10.3389/fnins.2022.858404

Peripheral veno-arterial extracorporeal membrane oxygenation (ECMO) artificially oxygenates and circulates blood retrograde from the femoral artery, potentially exposing the brain to asymmetric perfusion. Though ECMO patients frequently experience brain injury, neurologic exams and imaging are difficult to obtain. Diffuse correlation spectroscopy (DCS) non-invasively measures relative cerebral blood flow (rBF) at the bedside using an optical probe on each side of the forehead. In this study we observed interhemispheric rBF differences in response to mean arterial pressure (MAP) changes in adult ECMO recipients. We recruited 13 subjects aged 21-78 years (7 with cardiac arrest, 4 with acute heart failure, and 2 with acute respiratory distress syndrome). They were dichotomized Glasgow Coma Scale Motor score (GCS-M) into comatose (GCS-M ≤ 4; = 4) and non-comatose (GCS-M > 4; = 9) groups. Comatose patients had greater interhemispheric rBF asymmetry (ASYM ) vs. non-comatose patients over a range of MAP values (29 vs. 11%, = 0.009). ASYM in comatose patients resolved near a MAP range of 70-80 mmHg, while rBF remained symmetric through a wider MAP range in non-comatose patients. Correlations between post-oxygenator pCO or pH vs. ASYM were significantly different between comatose and non-comatose groups. Our findings indicate that comatose patients are more likely to have asymmetric cerebral perfusion.