Synthesis of Novel 1,4-Naphthoquinones Possessing Indole Scaffolds Using In(OTf)₃ in Solvent-Free Conditions

Novel 1,4-naphthoquinones possessing indole scaffolds were prepared by the reaction of 2-hydroxy-1,4-naphthoquinone-substituted salicylic aldehydes and indoles using In(OTf)₃ as a catalyst. The method has the advantages of simple operation, mild reaction conditions, and friendly environment.

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Bibliographic Details
Published inMolecules (Basel, Switzerland) Vol. 23; no. 8; p. 1954
Main Authors Yang, Xiaojuan, Wu, Liqiang
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 06.08.2018
MDPI
Subjects
1,4-naphthoquinone
Agricultural production
Cancer
Chemical engineering
green synthesis
indoles
Natural products
Pharmaceuticals
Pharmacy
R&D
Research & development
solvent-free
Solvents
substituted salicylic aldehydes
substituted salicylic aldehydes
indoles
solvent-free
1,4-naphthoquinone
green synthesis
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Summary:Novel 1,4-naphthoquinones possessing indole scaffolds were prepared by the reaction of 2-hydroxy-1,4-naphthoquinone-substituted salicylic aldehydes and indoles using In(OTf)₃ as a catalyst. The method has the advantages of simple operation, mild reaction conditions, and friendly environment.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules23081954