Severe head injury hastens age of onset of Alzheimer's disease

Head trauma has been found with greater frequency in the histories of Alzheimer patients than age-matched controls in some studies, but not in others. We hypothesized that events that accelerate neuron loss, such as significant head trauma, hasten the onset of symptoms of Alzheimer's disease in...

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Bibliographic Details
Published inJournal of the American Geriatrics Society (JAGS) Vol. 37; no. 10; p. 970
Main Authors Gedye, A, Beattie, B L, Tuokko, H, Horton, A, Korsarek, E
Format Journal Article
LanguageEnglish
Published United States 01.10.1989
Subjects
Age Factors
Aged
Alzheimer Disease - etiology
Craniocerebral Trauma - complications
Dementia - etiology
Humans
Injury Severity Score
Middle Aged
Retrospective Studies
Time Factors
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Summary:Head trauma has been found with greater frequency in the histories of Alzheimer patients than age-matched controls in some studies, but not in others. We hypothesized that events that accelerate neuron loss, such as significant head trauma, hasten the onset of symptoms of Alzheimer's disease in persons vulnerable to the disorder. Retrospective data on 148 probable Alzheimer patients and 33 demented controls were examined. Alzheimer patients with severe head injury before the age of 65 showed onset of symptoms at an earlier age than Alzheimer patients without head trauma.
ISSN:0002-8614
DOI:10.1111/j.1532-5415.1989.tb07283.x