Core-Shell Nanoencapsulation of α-Tocopherol by Blending Sodium Oleate and Rebaudioside A: Preparation, Characterization, and Antioxidant Activity

• Published in: Molecules (Basel, Switzerland) Vol. 23; no. 12; p. 3183
• Main Authors: He, Junbo, Shi, Hao, Huang, Shuangshuang, Han, Lijuan, Zhang, Weinong, Zhong, Qixin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.12.2018; MDPI
• Subjects: antioxidant activity; core-shell nanoencapsulation; Cosmetics; Fourier transforms; Hydrogen bonds; Lipids; Morphology; Nanoemulsions; Nanoparticles; Particle size; Pharmaceuticals; rebaudioside A; sodium oleate; Spectrum analysis; Surfactants; Vitamin E; α-tocopherol; sodium oleate; rebaudioside A; core-shell nanoencapsulation; antioxidant activity; α-tocopherol
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules23123183

Nanoencapsulation of α-tocopherol (α-TOC) by blending sodium oleate (NaOl) and rebaudioside A (RebA) was successfully prepared by self-assembly method under mild conditions. The optimized nanoemulsion showed the loading capacity of α-TOC was 30 wt% of sodium oleate. FTIR analysis suggested that hydrogen bonds and hydrophobic interactions were the major forces in α-TOC-NaOl/RebA complexes that were spherical and possessed well-distinguishable core-shell structures. The freeze-dried α-TOC-NaOl/RebA complexes had great stability under ambient conditions. The release profile of α-TOC showed a first-order kinetics reaching around 67.9% after 90 h at 25 °C. Nanoencapsulation improved dispersibility and greatly increased the antioxidant activity of α-TOC. Therefore, the stable α-TOC-NaOl/RebA core-shell complexes prepared from “generally recognized as safe” (GRAS) ingredients have great potential to supplement α-TOC in food and cosmetic products.