Quantitative 3D dynamic contrast‐enhanced (DCE) MR imaging of carotid vessel wall by fast T1 mapping using Multitasking

• Published in: Magnetic resonance in medicine Vol. 81; no. 4; pp. 2302 - 2314
• Main Authors: Wang, Nan, Christodoulou, Anthony G., Xie, Yibin, Wang, Zhenjia, Deng, Zixin, Zhou, Bill, Lee, Sangeun, Fan, Zhaoyang, Chang, Hyukjae, Yu, Wei, Li, Debiao
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2019
• Subjects: Adult; Aged; Aged, 80 and over; Algorithms; Area Under Curve; Arteriosclerosis; Atherosclerosis; Bulk density; Carotid Arteries - diagnostic imaging; Carotid Arteries - pathology; Carotid Artery Diseases - diagnostic imaging; carotid atherosclerosis; Contrast agents; Contrast Media - chemistry; Correlation coefficients; dynamic contrast‐enhanced (DCE) MRI; Female; Healthy Volunteers; Humans; Image Processing, Computer-Assisted - methods; Image quality; Imaging, Three-Dimensional; In vivo methods and tests; Kinetics; Magnetic Resonance Imaging; Male; Mapping; Medical imaging; Middle Aged; Motion; MR Multitasking; Multitasking; Normal Distribution; Phantoms, Imaging; quantitative imaging; Recovery; Reproducibility; Reproducibility of Results; Tensors; Time Factors; vasa vasorum; carotid atherosclerosis; quantitative imaging; MR Multitasking; vasa vasorum; dynamic contrast-enhanced (DCE) MRI
• ISSN: 0740-3194; 1522-2594; 1522-2594
• DOI: 10.1002/mrm.27553

Purpose To develop a dynamic contrast‐enhanced (DCE) MRI method capable of high spatiotemporal resolution, 3D carotid coverage, and T1‐based quantification of contrast agent concentration for the assessment of carotid atherosclerosis using a newly developed Multitasking technique. Methods 5D imaging with 3 spatial dimensions, 1 T1 recovery dimension, and 1 DCE time dimension was performed using MR Multitasking based on low‐rank tensor modeling, which allows direct T1 quantification with high spatiotemporal resolution (0.7 mm isotropic and 595 ms, respectively). Saturation recovery preparations followed by 3D segmented fast low angle shot readouts were implemented with Gaussian‐density random 3D Cartesian sampling. A bulk motion removal scheme was developed to improve image quality. The proposed protocol was tested in phantom and human studies. In vivo scans were performed on 14 healthy subjects and 7 patients with carotid atherosclerosis. Kinetic parameters including area under the concentration versus time curve (AUC), vp, Ktrans, and ve were evaluated for each case. Results Phantom experiments showed that T1 measurements using the proposed protocol were in good agreement with reference value (R2=0.96). In vivo studies demonstrated that AUC, vp, and Ktrans in the patient group were significantly higher than in the control group (0.63 ± 0.13 versus 0.42 ± 0.12, P < 0.001; 0.14 ± 0.05 versus 0.11 ± 0.03, P = 0.034; and 0.13 ± 0.04 versus 0.08 ± 0.02, P < 0.001, respectively). Results from repeated subjects showed good interscan reproducibility (intraclass correlation coefficient: vp, 0.83; Ktrans, 0.87; ve, 0.92; AUC, 0.94). Conclusion Multitasking DCE is a promising approach for quantitatively assessing the vascularity properties of the carotid vessel wall.